CYTOKINE STORM - IMMUNE SYSTEM

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   Yes, What a cytokines storm does to the body is essentially creates an absorbent amount of TNF alpha production, which results in the body having an over stimulated immune system. Cytokines are soluble hormone-like proteins that signal cell to cell. This situation causes the body to have a very negative anti-inflammatory reaction. 
This is what Wikipedia states:
 Wikipedia defines a cytokine storm as �a potentially fatal immune reaction consisting of a positive feedback loop between cytokines and immune cells. When the immune system is fighting pathogens, cytokines signal immune cells such as T-cells and macrophages to travel to the site of infection. In addition, cytokines activate those cells, stimulating them to produce more cytokines. Normally this feedback loop is kept in check by the body. However, in some instances, the reaction becomes uncontrolled, and too many immune cells are activated in a single place. The precise reason for this is not entirely understood. Cytokine storms have potential to do damage to body tissues and organs. If a cytokine storm occurs in the lungs, for example, fluids and immune cells such as macrophages may accumulate and eventually block off the air passageways. It is theorized that cytokine storms were responsible for many of the deaths during the 1918 influenza pandemic, which killed a disproportionate number of young adults. In this case, a healthy immune system may have been a liability rather than an asset. A 2003 report in the Journal of Experimental Medicine demonstrates the possibility of preventing a cytokine storm. A few days after T-cells are activated, they produce a molecule called OX40. OX40 binds to receptors on T-cells, preventing them from dying and increasing cytokine production. A combined protein, OX40-immunoglobin (OX40-Ig), prevents OX40 from reaching the T-cell receptors, thus reducing the T-cell response. Experiments in mice have demonstrated that OX40-Ig can reduce the symptoms associated with an immune overreaction while allowing the immune system to fight off the virus successfully.�

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Guests Members Profile Send Private Message Find Members Posts Add to Buddy List Guest Group	Post Options Post Reply Quote Guests Thanks(0) Quote Reply Posted: February 17 2006 at 9:55am
	Yes, What a cytokines storm does to the body is essentially creates an absorbent amount of TNF alpha production, which results in the body having an over stimulated immune system. Cytokines are soluble hormone-like proteins that signal cell to cell. This situation causes the body to have a very negative anti-inflammatory reaction. This is what Wikipedia states: Wikipedia defines a cytokine storm as �a potentially fatal immune reaction consisting of a positive feedback loop between cytokines and immune cells. When the immune system is fighting pathogens, cytokines signal immune cells such as T-cells and macrophages to travel to the site of infection. In addition, cytokines activate those cells, stimulating them to produce more cytokines. Normally this feedback loop is kept in check by the body. However, in some instances, the reaction becomes uncontrolled, and too many immune cells are activated in a single place. The precise reason for this is not entirely understood. Cytokine storms have potential to do damage to body tissues and organs. If a cytokine storm occurs in the lungs, for example, fluids and immune cells such as macrophages may accumulate and eventually block off the air passageways. It is theorized that cytokine storms were responsible for many of the deaths during the 1918 influenza pandemic, which killed a disproportionate number of young adults. In this case, a healthy immune system may have been a liability rather than an asset. A 2003 report in the Journal of Experimental Medicine demonstrates the possibility of preventing a cytokine storm. A few days after T-cells are activated, they produce a molecule called OX40. OX40 binds to receptors on T-cells, preventing them from dying and increasing cytokine production. A combined protein, OX40-immunoglobin (OX40-Ig), prevents OX40 from reaching the T-cell receptors, thus reducing the T-cell response. Experiments in mice have demonstrated that OX40-Ig can reduce the symptoms associated with an immune overreaction while allowing the immune system to fight off the virus successfully.�

Guests Members Profile Send Private Message Find Members Posts Add to Buddy List Guest Group	Post Options Post Reply Quote Guests Thanks(0) Quote Reply Posted: February 17 2006 at 9:54am
	April, do you have anything regarding experimental therapies used to prevent/cure the cytokine storm?

Guests Members Profile Send Private Message Find Members Posts Add to Buddy List Guest Group	Post Options Post Reply Quote Guests Thanks(0) Quote Reply Posted: February 17 2006 at 9:53am
	Your own immune system actually kills you. This virus is truly amazing...

Guests Members Profile Send Private Message Find Members Posts Add to Buddy List Guest Group	Post Options Post Reply Quote Guests Thanks(0) Quote Reply Posted: February 17 2006 at 9:49am
	The Immune System and the 1918 Avian Flu Pandemic During the 918 Avian Flu Pandemic the strongest immune systems suffered the highest mortality rates. November 2005 issue of Scientific American. http://www.sciam.com Article excerpt: "In contrast, the 1918 pandemic strain was most lethal to otherwise healthy young adults in their 20s and 30s, in part because their immune systems were so hardy. Researchers studying that virus have discovered that it suppresses early immune responses, such as the body's release of interferon, which normally primes cells to resist attack. At the same time, the virus provokes an extreme immune overreaction known as a cytokine storm, in which signaling molecules called cytokines summon a ferocious assault on the lungs by immune cells.� Refering to a recnt study on the Avian flu (H5N1), Michael T Osterholm, director of the Center for Infectious Disease Research and Policy at the University of Minnesota School of Public Health states "This study confirms earlier work that H5N1 induces a cytokine 'storm,'" said "It helps us understand the pathophysiology of the disease." As a note: This affects those with a healthy immune system between the ages of 20 and 40. Edited by KillerFlu.net

Guests Members Profile Send Private Message Find Members Posts Add to Buddy List Guest Group	Post Options Post Reply Quote Guests Thanks(0) Quote Reply Posted: February 17 2006 at 5:56am
	This thread will be for discussing issues related to the immune system and Cytokine Storm. There are many people that are trying to boost their immune systems, which is a big mistake. We need to educate the public regarding this matter. If anyone has any information pertaining to the "cytokine storm", please share it.