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Tracking the next pandemic: Avian Flu Talk

Why an Ebola epidemic is spinning out of control

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    Posted: July 25 2014 at 12:09pm
Why an Ebola epidemic is spinning out of control


By Laurie Garrett, Special to CNN

updated 2:03 PM EDT, Thu July 24, 2014

Editor's note: Laurie Garrett is senior fellow for global health at the Council on Foreign Relations and a Pulitzer Prize-winning journalist

http://www.cnn.com/2014/07/24/opinion/garrett-ebola/
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Shoo, they have two or three infected people running around one of the most populace cities in the world.

What could possibly go wrong?

Thankfully enough, Ebola hemorrhagic fever isn't an airborne thing and you have to come into contact with body fluids. Could you imagine what a disease with 60% mortality rate that's airborne could do in that city?
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Post Options Post Options   Thanks (0) Thanks(0)   Quote onefluover Quote  Post ReplyReply Direct Link To This Post Posted: July 26 2014 at 9:47am
I dunno but they sure seem to be slinging bodily fluids around like Gatorade from a broken sprinkler.
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Post Options Post Options   Thanks (0) Thanks(0)   Quote CRS, DrPH Quote  Post ReplyReply Direct Link To This Post Posted: July 26 2014 at 10:08am
Originally posted by onefluover onefluover wrote:

I dunno but they sure seem to be slinging bodily fluids around like Gatorade from sprinklers.

I agree.  Concern on AFT about airborne diseases is a bit overplayed, as the effect of airborne disease is time limited and very short range. 

However, an Ebola patient who is churning out virus in saliva, perspiration, and eventually leaking blood and diarrhea can contaminate all sorts of surfaces before crashing & bleeding out.  

This is exactly how Noro virus spreads explosively on cruise ships - contaminated railings, door knobs, surfaces in toilets etc. 

I don't know that we've ever really had an Ebola outbreak extend into urban areas before, this is an interesting experiment.  Rural areas don't tend to have the hard, nonporous surfaces (stainless steel, plastic, etc.) that urban areas have, and I believe most of the Ebola in the bush is from direct, hands-on contact by family members with the ill.  

Let's watch and wait.  If a patient gets onto an international airplane, bar the door.
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Post Options Post Options   Thanks (0) Thanks(0)   Quote jacksdad Quote  Post ReplyReply Direct Link To This Post Posted: July 26 2014 at 11:27am
Judging by the way that the outbreak is maintaining it's momentum, West Africa does seem to have opened up all kinds of opportunities for this virus that the Congo couldn't afford it, but when you break it all down it's still spreading because of third world hygiene, distrust of modern medicine and downright irresponsible funeral practices.
I agree with Chuck about the concern over airborne transmission - while it would change the way this disease spreads, it's not a given that it would do it more efficiently by that route. More importantly, it would take some serious mutations to take it from a virus spread primarily by contact with bodily fluids to one that could be pushed out in the kind of long lived aerosols that influenza can produce with a sneeze. To do that, it would have to be able to specifically irritate the victim's airway which would require it to bind to completely different receptors to the ones that decades or even centuries have adapted it to. EBOV has been shown to infect epithelial cells in the airway, but it looks as though it's one of the ways it gets into the body, and not how it goes on to infect other hosts.
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Post Options Post Options   Thanks (0) Thanks(0)   Quote onefluover Quote  Post ReplyReply Direct Link To This Post Posted: July 26 2014 at 12:01pm
My thoughts exactly Chuck.

Though we over here are a whole differant world in precautions on the one hand we are also somewhat of an Idiocracy on the other hand. Many people just don't get it on how easy it is to spread simple germs on non-porous surfaces. The surfaces and germs are virtually everywhere people go. In many places they are layered a thousand times over. These are simple germs. Ebola can be added to the mix. We don't have to be exposed to an Ebola infected body. Bodily fluids end up everywhere. Look at HPV, Herpes. Or Hep A or even the other Heps can enter casually. Other common ones, yes, like Noro. Ebola can become endemic here. In fact, if the current outbreak is not stopped it will with certainty. It won't have to be airborne but I'm not convinced that it's not already in some way airborne transmissible.
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Post Options Post Options   Thanks (0) Thanks(0)   Quote jacksdad Quote  Post ReplyReply Direct Link To This Post Posted: July 26 2014 at 12:05pm
Originally posted by onefluover onefluover wrote:

It won't have to be airborne but I'm not convinced that it's not already in some way airborne transmissible.


Onefluover - I think you're right. It is to a certain extent, but not efficiently. Physical contact with a victim or fomite still seems to the principal means of transmission.
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Post Options Post Options   Thanks (0) Thanks(0)   Quote onefluover Quote  Post ReplyReply Direct Link To This Post Posted: July 26 2014 at 12:23pm
Thanks JD.

I don't mean to talk bad about people from our own country-or even theirs--or anybody for that matter-but there seems to be a percentage over here that are not much different from the culture over there. We now have all kinds of viruses and bacterium endemic over here in our more advanced society that didn't exist here not so very long ago. I'm beginning to worry that Ebola will soon add to that list. Which means once again the answer will have to come in a cure rather than isolating it over there.
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Post Options Post Options   Thanks (0) Thanks(0)   Quote Turboguy Quote  Post ReplyReply Direct Link To This Post Posted: July 26 2014 at 7:07pm
Originally posted by CRS, DrPH CRS, DrPH wrote:

Originally posted by onefluover onefluover wrote:

I dunno but they sure seem to be slinging bodily fluids around like Gatorade from sprinklers.

I agree.  Concern on AFT about airborne diseases is a bit overplayed, as the effect of airborne disease is time limited and very short range. 

However, an Ebola patient who is churning out virus in saliva, perspiration, and eventually leaking blood and diarrhea can contaminate all sorts of surfaces before crashing & bleeding out.  

This is exactly how Noro virus spreads explosively on cruise ships - contaminated railings, door knobs, surfaces in toilets etc. 

I don't know that we've ever really had an Ebola outbreak extend into urban areas before, this is an interesting experiment.  Rural areas don't tend to have the hard, nonporous surfaces (stainless steel, plastic, etc.) that urban areas have, and I believe most of the Ebola in the bush is from direct, hands-on contact by family members with the ill.  

Let's watch and wait.  If a patient gets onto an international airplane, bar the door.


How long is Ebola active in a fluid deposit? Is it an "As long as it's wet?" or like Hepatitis, "As long as it's there?"

And you're exactly right: It is not only currently interesting, but will get to be more and more if things start to get out of hand there.

Think we might start looking to close our borders if things go haywire?
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Post Options Post Options   Thanks (0) Thanks(0)   Quote Satori Quote  Post ReplyReply Direct Link To This Post Posted: July 26 2014 at 7:31pm

"close our borders " ???



HERE’S YOUR SECURE BORDER

http://www.theburningplatform.com/2014/07/17/heres-your-secure-border/



I ain't holding my breathLOL

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Post Options Post Options   Thanks (0) Thanks(0)   Quote CRS, DrPH Quote  Post ReplyReply Direct Link To This Post Posted: July 26 2014 at 7:40pm
Good stuff from the Canadians! 

Humans may be infected by handling sick or dead non-human primates and are also at risk when handling the bodies of deceased humans in preparation for funerals, suggesting possible transmission through aerosol droplets (2, 6, 28)


In the laboratory, infection through small-particle aerosols has been demonstrated in primates, and airborne spread among humans is strongly suspected, although it has not yet been conclusively demonstrated (1, 6, 13). The importance of this route of transmission is not clear. Poor hygienic conditions can aid the spread of the virus (6).


The virus can survive in liquid or dried material for a number of days (23). Infectivity is found to be stable at room temperature or at 4°C for several days, and indefinitely stable at -70°C (6, 20). Infectivity can be preserved by lyophilisation. (freeze-drying)


http://www.phac-aspc.gc.ca/lab-bio/res/psds-ftss/ebola-eng.php

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Post Options Post Options   Thanks (0) Thanks(0)   Quote onefluover Quote  Post ReplyReply Direct Link To This Post Posted: July 26 2014 at 8:00pm
-70 c is over -90 f. I once built a walkin in the classroom from scratch that I could not get below -50 f and that was with a V-6 compressor. Though there are other ways for a layman to obtain those temps in his garage. If freeze dried can be viable then...
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Post Options Post Options   Thanks (0) Thanks(0)   Quote onefluover Quote  Post ReplyReply Direct Link To This Post Posted: July 26 2014 at 9:55pm
American doctor in Liberia tests positive for Ebola virus

Published July 27th 2014
FoxNews.com

In this 2014 photo provided by the Samaritan's Purse aid organization, Dr. Kent Brantly, left, treats an Ebola patient at the Samaritan's Purse Ebola Case Management Center in Monrovia, Liberia. On Saturday, July 26, 2014, the North Carolina-based aid organization said Brantly tested positive for the disease and was being treated at a hospital in Monrovia. (AP Photo/Samaritan's Purse)
An American doctor working in the African country of Liberia has tested positive for the deadly Ebola virus, an aid organization said Saturday.

Samaritan's Purse, based in North Carolina, said in a statement that Dr. Kent Brantly was being treated at an isolation center in a hospital in Monrovia, Liberia's capital. Brantly is the medical director for the aid organization's case management center in the city.



Brantly, 33, has been working with Samaritan's Purse in Liberia since October 2013 as part of the charity's post-residency program for doctors, group spokeswoman Melissa Strickland told The Associated Press. The organization's website says he had worked as a family practice physician in Fort Worth, Texas.

The highly contagious virus is one of the most deadly diseases in the world. Photos of Brantly working in Liberia show him in white coveralls made of a synthetic material that he wore for hours a day while treating Ebola patients.

Brantly was quoted in a posting on the organization's website earlier this year about efforts to maintain an isolation ward for patients.

"The hospital is taking great effort to be prepared," Brantly said. "In past Ebola outbreaks, many of the casualties have been healthcare workers who contracted the disease through their work caring for infected individuals."

Strickland says that Brantly's wife and two children had been





living with him in Africa, but they are currently in the U.S.






"We ask everyone to please pray for him and his family," the statement from Samaritan's Purse concluded.

A woman who identified herself as Brantly's mother told the AP family members are declining comment at this time.

The deadly disease has killed at least 672 in several African countries since the outbreak began earlier this year.

The Associated Press contributed to this report.


www.foxnews.com/health/2014/07/27/american-doctor-in-liberia-tests-positive-for-ebola-virus/?intcmp=latestnews


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Post Options Post Options   Thanks (0) Thanks(0)   Quote CRS, DrPH Quote  Post ReplyReply Direct Link To This Post Posted: July 26 2014 at 10:33pm
Originally posted by onefluover onefluover wrote:

-70 c is over -90 f. I once built a walkin in the classroom from scratch that I could not get below -50 f and that was with a V-6 compressor. Though there are other ways for a layman to obtain those temps in his garage. If freeze dried can be viable then...

We store biological samples in those temps all the time. 

The ability to store viruses for long periods of time with minimal loss of viability is critical. Even more than most organisms, many viruses are fragile and degrade quickly unless stored at low temperatures. The ATCC® and BEI Resources collections offer a unique opportunity to study the stability of various viruses under different conditions. The ATCC® Virology Collection, which celebrates 50 years of operation in 2008, contains more than 2,500 different holdings spanning decades of storage time using many different storage methods. 


A retrospective study was performed to evaluate the short and long-term viability of various holdings of influenza virus within the ATCC® collection, using virus stocks that had been grown and titered as long ago as 1968 (40 years) up to as recently as 2007 (3 months). Influenza and parainfluenza viruses prepared from 1968 to 1992 were either in liquid form or were lyophilized, while preparations after 1992, were only stored in liquid form at -70°C or in vapor phase of liquid nitrogen (approximately -125°C). 


In addition, a prospective study was performed by holding viruses at -80°C, -20°C, 4°C, room temperature (~20°C) and 37°C for various lengths of time with periodic re-titration. All testing was performed in specific pathogen free embryonated chicken eggs in order to obtain the 50% chicken egg infectious dose (CEID50). Titers were then plotted and rate of decay (log of titer loss per unit time - D10 values) was calculated. When stored at -20°C, -70°C or in liquid nitrogen, most influenza and parainfluenza viruses maintained viability with no significant loss of titer over the study period. 


One influenza isolate was seen to lose approximately 1 log of titer over a 16 year period when stored at -70°C. This drop in viability opens the possibility of strain- to-strain differences in storage. Viruses stored at temperatures above -20°C showed a direct correlation between temperature and decay rate, with the virus stored at 37°C having the highest rate of decay. From these data, we conclude that of the various methods employed at ATCC® and BEI Resources for the storage of virus preparations, storage in liquid form in the vapor phase of liquid nitrogen offers the benefits of simple, safe storage and excellent recovery.

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um....... What?
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Post Options Post Options   Thanks (0) Thanks(0)   Quote onefluover Quote  Post ReplyReply Direct Link To This Post Posted: July 27 2014 at 5:32am
Interesting Chuck. So anyone with a home deep-freeze (most go -20 f) can store Ebola infected blood viably for still a very long time. You don't need a lab or lab quality or industrial quality freezing methods or equipment or science background to keep that and most other bugs viable for timing of an attack. To me, it's not so much the governments or people otherwise in very high places that I'm most worried about. It's the ***hole down the street.
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Post Options Post Options   Thanks (1) Thanks(1)   Quote CRS, DrPH Quote  Post ReplyReply Direct Link To This Post Posted: July 27 2014 at 10:43am
Originally posted by onefluover onefluover wrote:

Interesting Chuck. So anyone with a home deep-freeze (most go -20 f) can store Ebola infected blood viably for still a very long time. You don't need a lab or lab quality or industrial quality freezing methods or equipment or science background to keep that and most other bugs viable for timing of an attack.

That's correct, and that is one reason why our federal government is so buggy about bioterrorism.   If you have the training & motivation, it ain't that hard to do. 

This was the source for the quote above:


So yes, it would be possible to preserve samples of Ebola (in human blood, let's say) in rather primitive freezers, and the virus would remain viable for quite some time.  

Given all the action going on in Africa right now, like Boko Haram etc., it is just a matter of time before someone pulls this off.  Ebola would be the ideal candidate virus IMHO.
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Post Options Post Options   Thanks (1) Thanks(1)   Quote jacksdad Quote  Post ReplyReply Direct Link To This Post Posted: July 27 2014 at 1:03pm
I like this quote from Peter Piot, the Belgian researcher that discovered Ebola in 1976. He's apparently frustrated with the current outbreak because he says that "fundamentally, Ebola is easy to contain. It's not a question of needing high technology. It's about respecting the basics of hygiene, and about isolation, quarantine and protecting yourself - in particular protecting healthcare workers, because they are very exposed."

He also says that "what we're seeing is a pattern that's been repeated in nearly every single Ebola outbreak. It started in people who live in the forest, or in close contact with it, and it's then transmitted around hospitals....and then spreads further either at funerals or in households though close contact."

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I find it almost unbelievable that either Doctor, African or American would not have understood the risks and taken precautions for physical contact transmission. And if they did and still got it then it must be airborne viable at least to some degree. Maybe it wouldn't travel airborne to Burbank on the trade winds but if in close quarters that is still airborne. But even if it had zero airborne transmissibility, a contact to contact transmission could easily survive over here. Not rampant like over there but it could take hold even here.
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I have trouble seeing it spreading over here in anything but isolated cases and maybe family clusters before it dead ends. Africa's where this thing can find it's legs, but not here. No bushmeat, family funeral preparations or fleeing into the jungle to escape doctors when symptoms show.
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Originally posted by onefluover onefluover wrote:

I find it almost unbelievable that either Doctor, African or American would not have understood the risks and taken precautions for physical contact transmission. And if they did and still got it then it must be airborne viable at least to some degree. Maybe it wouldn't travel airborne to Burbank on the trade winds but if in close quarters that is still airborne. But even if it had zero airborne transmissibility, a contact to contact transmission could easily survive over here. Not rampant like over there but it could take hold even here.

Stuff happens, doctors aren't perfect, and when Ebola patients are puking/bleeding etc. all over, every surface gets contaminated.  

Airborne?  Not possible.  Very few pathogens spread by airborne means, mostly fungi spores (valley fever).  


There is a big difference between "airborne" and droplet transmission.  Droplet nuclei contaminate a room-sized space, that's about it.  Ebola is primarily a disease spread by contact (kissing a dead body per African rituals etc.)
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Post Options Post Options   Thanks (0) Thanks(0)   Quote Technophobe Quote  Post ReplyReply Direct Link To This Post Posted: July 27 2014 at 5:12pm
Thanks Chuck.  I can update my use of the English language now.  It appears that in the final stages (when everything bleeds) ebola is droplet transmissable.  I thought this classed as airborne, as did several press spokesmen.  I know better now.  Thanks again!
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Post Options Post Options   Thanks (0) Thanks(0)   Quote onefluover Quote  Post ReplyReply Direct Link To This Post Posted: July 27 2014 at 5:56pm
OK so "airborne" in that use makes sence to me. Ebola, like hepatitis is a blood-borne pathogen. I would only add that in tattooing, because of the very high mechanical frequency of strokes, the vibration will put off something similar to a vapor of potentially pathogenic laced blood into the air that when viewed under special lighting will resemble smoke and will travel virtually the entire room onto every surface. Of course right here right now we don't have to worry about that and Ebola but now that I've made some of you cringe, you should know that this is a true dirty little secret and one reason why I finely left the industry. However, we are not supposed to work on anybody with any of these type of diseases. But it is up to the client to be honest.
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Originally posted by onefluover onefluover wrote:

OK so "pathogen" in that use makes sence to me. Ebola, like hepatitis is a blood-borne pathogen. I would only add that in tattooing, because of the very high mechanical frequency of strokes, the vibration will put off something similar to a vapor of potentially pathogenic laced blood into the air that when viewed under special lighting will resemble smoke and will travel virtually the entire room onto every surface. Of course right here right now we don't have to worry about that and Ebola but now that I've made some of you cringe, you should know that this is a true dirty little secret and one reason why I finely left the industry. However, we are not supposed to work on anybody with any of these type of diseases. But it is up to the client to be honest.

Thanks!  Ebola is transmitted more easily than a true "blood-borne" pathogen, such as Hep B or C:

People can be exposed to Ebola virus from direct physical contact with body fluids like blood, saliva, stool, urine, sweat etc. of an infected person and soiled linen used by a patient.

This is why infection control is so daunting in a tropical environment.  Healthcare workers have to dress up as if they were working in a BSL 3 lab, which is exhausting.  If the virus is being shed in perspiration, nasal secretions, saliva etc., you can pretty much consider every surface in the HC setting to be contaminated with the stuff. 

Sort of like a tattoo parlor.  Shocked
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Post Options Post Options   Thanks (0) Thanks(0)   Quote onefluover Quote  Post ReplyReply Direct Link To This Post Posted: July 27 2014 at 6:35pm
Sorry. I meant airborne not pathogen in my quote above and edited it too late. Anyway.

Yeah. Hate to say it but :
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Post Options Post Options   Thanks (0) Thanks(0)   Quote jacksdad Quote  Post ReplyReply Direct Link To This Post Posted: July 27 2014 at 10:17pm
Couldn't agree more with your assessment of the situation, Chuck
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Reading a piece on MSN this am
http://news.ca.msn.com/world/ebola-fears-grow-in-nigeria-after-plane-scare
and it's talking about the city/country being 'on edge' and how they are trying to trace people who were on flights with the man who flew into city. They state it's almost impossible as the ones on his flights have travelled to other cities. They also state it's not 'catchable' until signs are showing (nice calming sentence) but then later in article they said he was vomiting and having diarrhea on one flight..... has anyone checked up on the poor staff who got stuck cleaning that plane/washroom?!?! They wouldn't have been in full protective gear like the doctors (who are catching it anyway).
Just saying... to me they'd be 'most exposed' as cleaning up the mess...
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Post Options Post Options   Thanks (0) Thanks(0)   Quote nc_girl Quote  Post ReplyReply Direct Link To This Post Posted: August 02 2014 at 3:02pm
but wasn't it found that the version of ebola in Reston, VA was in fact airborne?
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Post Options Post Options   Thanks (1) Thanks(1)   Quote Technophobe Quote  Post ReplyReply Direct Link To This Post Posted: August 02 2014 at 5:00pm
No, not exactly.  As Chuck says it depends on how you define airborne.  Yes it was transmitted between the pigs and monkeys by air, but they were shut up in the same "room".  This was just a dramatic demonstration of droplet transmission.  That is quite bad enough but not the same as airborne.  Airborne viruses survive and produce aerosols which travel much further and last far longer.
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His lips or pen are moving.
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Post Options Post Options   Thanks (0) Thanks(0)   Quote jacksdad Quote  Post ReplyReply Direct Link To This Post Posted: August 02 2014 at 5:42pm
The Reston strain was apparently transmitted between animals housed in the same facility, but it's significantly different from the other known strains that it causes no illness in humans. But here's one to keep you awake - it looks like Ebola strains can undergo recombination, which in theory means Reston and another strain could infect the same host and come up with something none of us would want to see. Confused


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Post Options Post Options   Thanks (1) Thanks(1)   Quote onefluover Quote  Post ReplyReply Direct Link To This Post Posted: August 02 2014 at 5:48pm
Kind of like the differance between blowing a spit wad through a straw accross the room and the smell from hundreds of feet away, indoor or out of a Colorado joint... -I mean, marijuana cigarette.
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Post Options Post Options   Thanks (0) Thanks(0)   Quote jacksdad Quote  Post ReplyReply Direct Link To This Post Posted: August 02 2014 at 5:50pm
Something like that, onefluover LOL
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Post Options Post Options   Thanks (1) Thanks(1)   Quote onefluover Quote  Post ReplyReply Direct Link To This Post Posted: August 02 2014 at 5:53pm
couldn't help that.
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Post Options Post Options   Thanks (0) Thanks(0)   Quote CRS, DrPH Quote  Post ReplyReply Direct Link To This Post Posted: August 02 2014 at 6:48pm
Originally posted by Technophobe Technophobe wrote:

No, not exactly.  As Chuck says it depends on how you define airborne.  Yes it was transmitted between the pigs and monkeys by air, but they were shut up in the same "room".  This was just a dramatic demonstration of droplet transmission.  That is quite bad enough but not the same as airborne.  Airborne viruses survive and produce aerosols which travel much further and last far longer.

Thanks, great explanation!!  

The concept of "airborne" disease is much misused by the media and others as I've said.   Virus or bacterial diseases spread through the air are very close-quarter phenomena, "droplet nuclei."  You don't catch the flu if you are walking outside, UNLESS you are in a Shanghai wet market and are exposed to aerosols from plucking chickens etc.!!  Those are just larger, mechanically-induced droplet nuclei which don't extend more than a few dozen yards, tops.   We don't catch disease by walking around outside, that is the long disproven "miasma" theory of the 1800s. 

The foot & mouth disease (FMD) virus is one that does spread through the air by aerosol for considerable distances, and fortunately, us people aren't very susceptible to it (it can cause a mild human case).  I remember this vividly, as friends of mine in Britain reported the farmer suicides, prayers broadcast by radio etc.  

The outbreak of foot-and-mouth disease in the United Kingdom in 2001 caused a crisis in British agriculture and tourism. This epizootic saw 2,000 cases of the disease in farms across most of the British countryside. Over 10 million sheep and cattle were killed [1] in an eventually successful attempt to halt the disease.  By the time the disease was halted by October 2001, the crisis was estimated to have cost the United Kingdom £8bn ($16bn).
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