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Tracking the next pandemic: Avian Flu Talk

aids drug for ebola cure?
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drumfish View Drop Down
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    Posted: September 26 2014 at 12:30am
Added On September 26, 2014
CNN explores an Ebola isolation unit where a doctor is successfully treating patients with a medication meant for HIV

http://www.cnn.com/video/standard.html?/video/world/2014/09/26/dnt-cohen-dr-treating-ebola-with-hiv-drug.cnn&iref=allsearch&video_referrer=http%3A%2F%2Fwww.cnn.com%2Fsearch%2F%3Fquery%3Debola%26x%3D0%26y%3D0%26primaryType%3Dmixed%26sortBy%3Drelevance%26intl%3Dfalse
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Points: 88450 		Post Options Post Options   Thanks (0) Thanks(0)   Quote Technophobe Quote  Post ReplyReply Direct Link To This Post Posted: September 26 2014 at 12:47am
Wow!  I almost wish he was my doctor.  If he could come here I would. 

Not only is he having an amazing success rate, but he came up with the idea (repurposing drugs which were already safety tested) in the bush with no facilities, few staff and using just his own intelligence. 

His patients have a better survival rate than western medicine with all its staff and rescources.  Here in the west 6 people have been treated for ebola, 1 died.  That is a success rate of 83% .  His success rate is 93%.

Can we chuck Chan out and make him the head of the WHO?  If not, why not?
How do you tell if a politician is lying?
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Points: 3115 		Post Options Post Options   Thanks (0) Thanks(0)   Quote drumfish Quote  Post ReplyReply Direct Link To This Post Posted: September 26 2014 at 12:55am
I hope its for real. Chan is a disgrace.
The drug does not cure HIV so I hope that it is not just suppressing thus allowing for a relapse. I did not find a written report just the video.
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saeed abdul wahab View Drop Down
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Post Options Post Options   Thanks (0) Thanks(0)   Quote saeed abdul wahab Quote  Post ReplyReply Direct Link To This Post Posted: September 26 2014 at 1:31am
yes let work arrond it since they are all virus for all you know hiv drugs when worked upon can cure ebola and vice versa
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Points: 88450 		Post Options Post Options   Thanks (0) Thanks(0)   Quote Technophobe Quote  Post ReplyReply Direct Link To This Post Posted: September 26 2014 at 2:11am
A lot of antibiotics work by suppressing the bacteria's ability to replicate, giving the body a chance to "catch up".  I suspect this is what the antiviral does in this case.  Ebola's lethality (as far as we know) is, at least in part, due to its stealth tactics, which causes the host's slow immune response.

This is what Wikipedia has to say about lamivudine:

Lamivudine is an analogue of cytidine. It can inhibit both types (1 and 2) of HIV reverse transcriptase and also the reverse transcriptase of hepatitis B. It is phosphorylated to active metabolites that compete for incorporation into viral DNA. They inhibit the HIV reverse transcriptase enzyme competitively and act as a chain terminator of DNA synthesis. The lack of a 3'-OH group in the incorporated nucleoside analogue prevents the formation of the 5' to 3' phosphodiester linkage essential for DNA chain elongation, and therefore, the viral DNA growth is terminated.

Lamivudine is administered orally, and it is rapidly absorbed with a bio-availability of over 80%. Some research suggests that lamivudine can cross the blood–brain barrier. Lamivudine is often given in combination with zidovudine, with which it is highly synergistic. Lamivudine treatment has been shown to restore zidovudine sensitivity of previously resistant HIV. Lamivudine showed no evidence of carcinogenicity or mutagenicity in in vivo studies in mice and rats at doses from 10 to 58 times those used in humans.

This drug also treats hepB. 

By inhibiting the DNA replication of the viruses it would seem to be a viral reproduction suppressant.  I am no expert here, but the jigsaw pieces seem to fit.
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If this is for real and (not some scam) My worry was is all the virus actuall cleared from the patient? If not it could return. Or worse if it did return perhaps the immune system could be at a point where it could keep virus in check but produce an asymptomatic carrier. I just don't know enough to say. But I know just enough to worry. It would be great if it works, but it is a real life experiment without controls if something went wrong it could effect more than just the patient.
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Points: 88450 		Post Options Post Options   Thanks (0) Thanks(0)   Quote Technophobe Quote  Post ReplyReply Direct Link To This Post Posted: September 26 2014 at 4:08am
Well, we could test for that here in the west.  I hope someone does.  I'm not holding my breath though, as the question arises "Who will pay for the tests?". 

GSK make the stuff we could lobby them to look into this.
customer.relations@gsk.com
The lobby would need lots of us to stand a chance of succeeding.  I would recommend we took the line of "Look how good this would be for your customer relations/stock prices."

If anyone is interested let me know.  Not much point in lobbying if you do not have many lobbyists.
How do you tell if a politician is lying?
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Points: 2080 		Post Options Post Options   Thanks (0) Thanks(0)   Quote WillobyBrat Quote  Post ReplyReply Direct Link To This Post Posted: September 26 2014 at 4:15am
I agree with you for two reasons: 

1, Humanitarian - yes even I can be an humanitarian on occasions.
2, Enlightened self-interest - we have a problem with illegal imigration into this country via Calais which brings many Eastern and African people here.  This country would then act as a launch platform for ebola to become airborne and reach the rest of the world.  By airborne, I mean British Airways, Pan Am, Air NZ, Quantas etc..  So lets stir up GSK!
I like Ike
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Cost of pills

http://www.goodrx.com/lamivudine
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The amount of time to test for that?
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Points: 3115 		Post Options Post Options   Thanks (0) Thanks(0)   Quote drumfish Quote  Post ReplyReply Direct Link To This Post Posted: September 27 2014 at 1:22am
I know there was Japanese firm that offered an antiviral it is an interesting idea. Usually a flu shot is "free" with insurance. I asked the pharmacist how much the shingles vaccine was he said if you are over 60 insurance will usually pay half, with out insurance its about $200. I don't know how long the Dr in this story had people taking the drug but if it was a month according to the cost I found on the web it would be less than shingles vaccine.
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