Another new strain of avian and human strains

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   Hi all, 
Just reading this from Poultry World News - doesn't sound good to me - thoughts from ppl who understand the science behind this..???

Novel AI virus discovered in China

0 1503 Broilers 

Chinese researchers who analysed influenza viruses from poultry in live-bird markets say they have discovered a novel H5N9 virus that represents a hybrid of the highly pathogenic H5N1 avian flu virus and a human H7N9 virus, along with other elements.

Novel AI virus discovered in China
Photo: Mark Pasveer 

The Center for Infectious Disease Research and Policy (CIDRAP) of the University of Minnesota reports that Chinese researchers who analysed influenza viruses from poultry in live-bird markets say they have discovered a novel H5N9 virus that represents a hybrid of the highly pathogenic H5N1 avian flu virus and a human H7N9 virus, along with other elements.
The authors took samples in 2013 from seven chickens, a quail, and a duck at two live-bird markets in Hangzhou, a city in Zhejiang province, where human H7N9 cases had occurred, according to their Jun 17 report in the Journal of Virology. The report does not indicate that any of the birds were sick.

13 viruses

The team isolated 13 viruses from the samples: 1 H5N1, 2 H5N9, 4 H9N2, and 6 H7N9. By sequencing the whole genomes of the two H5N9 isolates, the researchers determined that their hemagglutinin (H) protein matched that of a 2012 H5N1 isolate from Vietnam, while their neuraminidase (N) component derived from a human H7N9 isolate from Hangzhou. They also noted that the structure of the H cleavage site is characteristic of highly pathogenic viruses. The six internal genes resembled those of H5N1, H7N9, and H9N2 viruses.
The pathogenicity of the novel virus in mammals was tested by exposing mice to various doses. Some mice exposed to the highest doses died, but mice that received lower doses didn't get sick, and the authors concluded that the virus causes low mortality in mice. They also found that the virus didn't spread from infected mice to others placed with them. The team determined that the novel H5N9 virus prefers avian-type cell receptors, known as alpha2,3 sialic acid, rather than the human-type receptor, called alpha2,6. They said this may explain why the virus caused low mortality in mice.

Live bird markets potential transmission risk to public health and poultry industry

The report says a highly pathogenic H5N9 virus was found in turkeys in Ontario in 1966, and low-pathogenic H5N9 strains have been found in mallards, northern pintails, and occasionally chickens in the past few decades. But the novel virus is "totally different" from those, the authors concluded. "This newly isolated H5N9 virus is a highly pathogenic reassortant virus originating from H5N1, H7N9, and H9N2 subtypes," they wrote. "Live bird markets represent a potential transmission risk to public health and the poultry industry."

  by World Poultry  Jun 26, 2015 
http://www.worldpoultry.net/Broilers/Health/2015/6/Novel-AI-virus-discovered-in-China-1782785W/?cmpid=NLC|worldpoultry|2015-06-26|Novel_AI_virus_discovered_in_China

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newbie1 Members Profile Send Private Message Find Members Posts Add to Buddy List Adviser Group Joined: July 29 2014 Location: Western Canada Status: Offline Points: 2345	Post Options Post Reply Quote newbie1 Report Post Thanks(0) Quote Reply Topic: Another new strain of avian and human strains Posted: June 27 2015 at 10:29am
	Hi all, Just reading this from Poultry World News - doesn't sound good to me - thoughts from ppl who understand the science behind this..??? Novel AI virus discovered in China 0 1503 Broilers Chinese researchers who analysed influenza viruses from poultry in live-bird markets say they have discovered a novel H5N9 virus that represents a hybrid of the highly pathogenic H5N1 avian flu virus and a human H7N9 virus, along with other elements. Novel AI virus discovered in China Photo: Mark Pasveer The Center for Infectious Disease Research and Policy (CIDRAP) of the University of Minnesota reports that Chinese researchers who analysed influenza viruses from poultry in live-bird markets say they have discovered a novel H5N9 virus that represents a hybrid of the highly pathogenic H5N1 avian flu virus and a human H7N9 virus, along with other elements. The authors took samples in 2013 from seven chickens, a quail, and a duck at two live-bird markets in Hangzhou, a city in Zhejiang province, where human H7N9 cases had occurred, according to their Jun 17 report in the Journal of Virology. The report does not indicate that any of the birds were sick. 13 viruses The team isolated 13 viruses from the samples: 1 H5N1, 2 H5N9, 4 H9N2, and 6 H7N9. By sequencing the whole genomes of the two H5N9 isolates, the researchers determined that their hemagglutinin (H) protein matched that of a 2012 H5N1 isolate from Vietnam, while their neuraminidase (N) component derived from a human H7N9 isolate from Hangzhou. They also noted that the structure of the H cleavage site is characteristic of highly pathogenic viruses. The six internal genes resembled those of H5N1, H7N9, and H9N2 viruses. The pathogenicity of the novel virus in mammals was tested by exposing mice to various doses. Some mice exposed to the highest doses died, but mice that received lower doses didn't get sick, and the authors concluded that the virus causes low mortality in mice. They also found that the virus didn't spread from infected mice to others placed with them. The team determined that the novel H5N9 virus prefers avian-type cell receptors, known as alpha2,3 sialic acid, rather than the human-type receptor, called alpha2,6. They said this may explain why the virus caused low mortality in mice. Live bird markets potential transmission risk to public health and poultry industry The report says a highly pathogenic H5N9 virus was found in turkeys in Ontario in 1966, and low-pathogenic H5N9 strains have been found in mallards, northern pintails, and occasionally chickens in the past few decades. But the novel virus is "totally different" from those, the authors concluded. "This newly isolated H5N9 virus is a highly pathogenic reassortant virus originating from H5N1, H7N9, and H9N2 subtypes," they wrote. "Live bird markets represent a potential transmission risk to public health and the poultry industry." by World Poultry Jun 26, 2015 http://www.worldpoultry.net/Broilers/Health/2015/6/Novel-AI-virus-discovered-in-China-1782785W/?cmpid=NLC\|worldpoultry\|2015-06-26\|Novel_AI_virus_discovered_in_China
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jacksdad Members Profile Send Private Message Find Members Posts Add to Buddy List Executive Admin Joined: September 08 2007 Location: San Diego Status: Offline Points: 47251	Post Options Post Reply Quote jacksdad Report Post Thanks(0) Quote Reply Posted: June 27 2015 at 4:39pm
	Scary - the whole reassortment thing was complicated enough when it was a few strains mixing. Now we have H7N9 - a fairly new novel strain itself - already swapping spit with other hi-path viruses. We don't get time to adjust to a new virus appearing before it's spawning a completely new one. And the pace seems to be accelerating. I suspect we won't be talking about the next pandemic virus as it emerges - I think it'll arrive without a fanfare, probably in a market town in a Chinese province like Guangdong, and initially the authorities will do what they always do and suppress the news. By the time we hear about it, it'll have broken through all quarantines and hit the ground running, going global in a couple of months at most. It's all a numbers game, but that really doesn't bode well when the rate at which novel viruses are popping up is increasing.
	"Buy it cheap. Stack it deep" "Any community that fails to prepare, with the expectation that the federal government will come to the rescue, will be tragically wrong." Michael Leavitt, HHS Secretary.