Nasty filoviruses!

This is a good little article on the filoviridae, of which Ebola is but one....

http://acsh.org/news/2016/08/15/ebolas-dangerous-cousins-beware-the-neglected-filoviruses/?source=realclearscience.com

When I first started studying these things in 1979, I was particularly concerned with Marburg due to its outbreak in Germany (where it got the cool name!).

I was also obsessed with Lassa Fever, caused by the arenavirus:

http://www.who.int/mediacentre/factsheets/fs179/en/

These bugs are out there, circulating in bats & other rodents, primates, and other hosts.

It is only a matter of time until one of these things breaks out in a big way, the Ebola outbreak of west Africa was a warning shot across the bow.

Be safe, Chuck!

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CRS, DrPH

Here's a new one that I hadn't heard from before....the harder we look, the more we find!!

Date: August 25, 2016

Source: US Army Medical Research Institute of Infectious Diseases

Summary: Scientists have identified a new 'multicomponent' virus --one containing different segments of genetic material in separate particles -- that can infect animals. This new pathogen was isolated from several species of mosquitoes in Central and South America. GCXV does not appear to infect mammals; however, the team also isolated a related virus, Jingmen tick virus, from a nonhuman primate.

Scientists have identified a new "multicomponent" virus -- one containing different segments of genetic material in separate particles -- that can infect animals, according to research published today in the journal Cell Host & Microbe.

This new pathogen, called Guaico Culex virus (GCXV), was isolated from several species of mosquitoes in Central and South America. GCXV does not appear to infect mammals, according to first author Jason Ladner, Ph.D., of the U.S. Army Medical Research Institute of Infectious Diseases (USAMRIID). However, the team also isolated a related virus -- called Jingmen tick virus, or JMTV -- from a nonhuman primate. Further analysis demonstrates that both GCXV and JMTV belong to a highly diverse and newly discovered group of viruses called the Jingmenvirus group.

Taken together, the research suggests that the host range of this virus group is quite diverse -- and highlights the potential relevance of these viruses to animal and human health.
"Animal viruses typically have all genome segments packaged together into a single viral particle, so only one of those particles is needed to infect a host cell," Ladner explained. "But in a multicomponent virus, the genome is divided into multiple pieces, with each one packaged separately into a viral particle. At least one particle of each type is required for cell infection."
Several plant pathogens have this type of organization, but the study published today is the first to describe a multicomponent virus that infects animals.

Working with collaborators including the University of Texas Medical Branch and the New York State Department of Health, the USAMRIID team extracted and sequenced virus from mosquitoes collected around the world. The newly discovered virus is named for the Guaico region of Trinidad, where the mosquitoes that contained it were first found.

In collaboration with a group at the University of Wisconsin-Madison, the USAMRIID investigators also found the first evidence of a Jingmenvirus in the blood of a nonhuman primate, in this case a red colobus monkey living in Kibale National Park, Uganda. The animal showed no signs of disease when the sample was taken, so it is not known whether the virus had a pathogenic effect.

Jingmenviruses were first described in 2014 and are related to flaviviruses -- a large family of viruses that includes human pathogens such as yellow fever, West Nile and Japanese encephalitis viruses. "One area we are focused on is the identification and characterization of novel viruses," said the paper's senior author Gustavo Palacios, Ph.D., who directs USAMRIID's Center for Genome Sciences. "This study allowed us to utilize all our tools -- and even though this virus does not appear to affect mammals, we are continuing to refine those tools so we can be better prepared for the next outbreak of disease that could have an impact on human health."

While it is difficult to predict, experts believe that the infectious viruses most likely to emerge next in humans are those already affecting other mammals, particularly nonhuman primates.

Story Source:
The above post is reprinted from materials provided by US Army Medical Research Institute of Infectious Diseases. .

Journal Reference:

Ladner et al. A Multicomponent Animal Virus Isolated from Mosquitoes. Cell Host & Microbe, 2016 DOI: 10.1016/j.chom.2016.07.011

US Army Medical Research Institute of Infectious Diseases. "Newly discovered 'multicomponent' virus can infect animals." ScienceDaily. ScienceDaily, 25 August 2016. www.sciencedaily.com/releases/2016/08/160825141714.htm
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CRS, DrPH