Risk assessment of recent Egyptian H5N1

Message Topic Search Topic Options Post Reply Create New Topic Printable Version Translate Topic

This is a really long but interesting report on Egyptian H5N1 so I'm only posting the abstract and the link!

"Risk assessment of recent Egyptian H5N1 influenza viruses"

Abstract

Highly pathogenic avian influenza (HPAI) viruses of the H5N1 subtype are enzootic in poultry populations in different parts of the world, and have caused numerous human infections in recent years, particularly in Egypt. However, no sustained human-to-human transmission of these viruses has yet been reported. We tested nine naturally occurring Egyptian H5N1 viruses (isolated in 2014–2015) in ferrets and found that three of them transmitted via respiratory droplets, causing a fatal infection in one of the exposed animals. All isolates were sensitive to neuraminidase inhibitors. However, these viruses were not transmitted via respiratory droplets in three additional transmission experiments in ferrets. Currently, we do not know if the efficiency of transmission is very low or if subtle differences in experimental parameters contributed to these inconsistent results. Nonetheless, our findings heighten concern regarding the pandemic potential of recent Egyptian H5N1 influenza viruses.

http://www.nature.com/articles/srep38388

Author	Message Topic Search Topic Options Post Reply Create New Topic Printable Version Translate Topic
arirish Members Profile Send Private Message Find Members Posts Add to Buddy List Admin Group Joined: June 19 2013 Location: Arkansas Status: Offline Points: 39215	Post Options Post Reply Quote arirish Report Post Thanks(1) Quote Reply Topic: Risk assessment of recent Egyptian H5N1 Posted: December 08 2016 at 9:01am
	This is a really long but interesting report on Egyptian H5N1 so I'm only posting the abstract and the link! "Risk assessment of recent Egyptian H5N1 influenza viruses" Abstract Highly pathogenic avian influenza (HPAI) viruses of the H5N1 subtype are enzootic in poultry populations in different parts of the world, and have caused numerous human infections in recent years, particularly in Egypt. However, no sustained human-to-human transmission of these viruses has yet been reported. We tested nine naturally occurring Egyptian H5N1 viruses (isolated in 2014–2015) in ferrets and found that three of them transmitted via respiratory droplets, causing a fatal infection in one of the exposed animals. All isolates were sensitive to neuraminidase inhibitors. However, these viruses were not transmitted via respiratory droplets in three additional transmission experiments in ferrets. Currently, we do not know if the efficiency of transmission is very low or if subtle differences in experimental parameters contributed to these inconsistent results. Nonetheless, our findings heighten concern regarding the pandemic potential of recent Egyptian H5N1 influenza viruses. http://www.nature.com/articles/srep38388
	Buy more ammo!

Dutch Josh Members Profile Send Private Message Find Members Posts Add to Buddy List Adviser Group Joined: May 01 2013 Location: Arnhem-Netherla Status: Offline Points: 95567	Post Options Post Reply Quote Dutch Josh Report Post Thanks(0) Quote Reply Posted: December 08 2016 at 9:47am
	From Henry Niman's recombinomics site : Commentary . H5N1 Mating and Mutating >>That could happen if the bird flu virus got into an animal, most probably a pig, which can harbor the kind of influenza virus that affects people, mate and mutate. There is not yet any sign that has happened << There are VERY clear signs that dual infections have happened, particularly in the isolates from Vietnam and Thailand. Isolates from both countries have polymorphisms not found in other H5N1 isolates. The polymorphisms however, can be readily detected in mammalian isolates from pigs and humans. The virus mates (via dual infection) and mutates (via recombination) on a very regular basis, and the mating is quite evidentin the isolates from fatal human cases in Vietnam and Thailand.
	We cannot solve our problems with the same thinking we used when we created them. ~Albert Einstein