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Mutated H7N9 now more infectious to humans

Printed From: Avian Flu Talk
Category: General Discussion
Forum Name: Latest News
Forum Description: (Latest Breaking News)
URL: http://www.avianflutalk.com/forum_posts.asp?TID=36277
Printed Date: November 13 2018 at 2:51pm


Topic: Mutated H7N9 now more infectious to humans
Posted By: Albert
Subject: Mutated H7N9 now more infectious to humans
Date Posted: March 23 2017 at 5:33am
(Avian flu) Mutated virus, more dangerous to humans, detected

A research team from the University of Hong Kong has identified a mutation in the H7N9 virus, which may explain why there has been a major outbreak of the avian flu strain on the mainland since autumn last year.
More than 500 people have been infected with the bird flu virus since then. More than a fifth of them have died.
One of the team's key investigators, Professor Chen Honglin, said the mutation has made the H7N9 virus much more infectious to humans.
Chen said the mutation emerged as early as 2000. He said by 2012 or 2013, almost all H9N2 virus carried this mutation. -RTHK

http://www.thestandard.com.hk/breaking-news.php?id=86494


Comment:  It seems that this thing is a hair away from going pandemic.  We will be lucky if it doesn't within the next 12 months.


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Replies:
Posted By: Eight
Date Posted: March 23 2017 at 10:02am
Of note is the otherwise slightly decreased mortality rate. It could be an artifact, but with increased cases and an apparently lower mortality rate that would seem to indicate attenuation and therefore host adaption. But, hey, who knows. 

Also, this is only increasing the rate at which it infects humans from, presumably, the infected avian hosts. A hair away from a pandemic, in my eyes, is the emergence of human-to-human transmission. There are some cases where this might have happened, but we aren't seeing a lot of that just yet. This is bad news, since it will increase the chance for such mutations to arise, but it's still a step or so away from sustained human-to-human.

Winter is coming to a close. Hopefully some of these strains die with it.

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Such a beautiful number, eight.


Posted By: jacksdad
Date Posted: March 23 2017 at 12:31pm
That does tend to be a pattern with viruses like influenza - a trade of between it's ability to better infect a new host, and kill it. How much H7N9 might drop it's CFR is anyone's guess if it did go efficiently H2H, but it's starting with the bar set pretty high right now.

We're fortunate that it seems to be geographically stuck right now, because things are going to start getting chilly in the southern hemisphere soon.




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"Buy it cheap. Stack it deep"
"Any community that fails to prepare, with the expectation that the federal government will come to the rescue, will be tragically wrong." Michael Leavitt, HHS Secretary.


Posted By: Albert
Date Posted: March 24 2017 at 1:20am
For years people have speculated that there is a relationship between mortality rate and transmission, and as the mortality rate decreases, the better chance of increased transmission as is begins to mutate.  That has always been a question mark for me, and the only thing people had to go on was using H5N1 as the model with an extremely high mortality rate.  This may not be the case as we are seeing the mortality rate increase with H7N9 along with the transmission.   Hopefully we don't find out, but at this rate, as the mortality increases, so is the transmission.    

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Posted By: CRS, DrPH
Date Posted: March 24 2017 at 11:48pm
Great discussion!  The surface receptors of strictly avian influenza like H5N1 and H7N9 must acquire the ability to attach to human sites efficiently, which is why it takes time for these viruses to evolve. 

I've always been a skeptic of H2H transmission with H5N1, and believed that cases occurred during the animal husbandry of keeping fowl, where cases were likely to really inhale a very high infectious dose deep into the lungs (from cleaning cages, disposing of dead birds etc.) 

It seems likely to me that, as the strictly avian viruses mutate to cause human illness more easily, they may also lose some of the traits that result in high morbidity and mortality in human hosts.  I can't find a good reference for this, but it does seem to hold true.  

I read papers like this late at night to help fall asleep!!  This has many answers to your questions: 

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1865597/" rel="nofollow - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1865597/

Off to bed now!  Clap


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CRS, DrPH


Posted By: Albert
Date Posted: March 25 2017 at 3:51am
It appears that various organizations believe an H7N9 pandemic is imminent.  This is not looking good.  My guess would be 1 - 2 years with H7N9 on the outside, or never.   This one is not looking good.

Stronger Precautions Urged for Bird Flu

CHINA - Two international organizations have stressed the high possibility of human-to-human transmission of the H7N9 virus, which saw the biggest outbreak in China over the past winter since first being reported in China in 2013.

The organizations urged the Chinese government to take more precautionary measures to prevent a possible bird flu epidemic.

"Experts agree that it is not a question of if, but when the virus will adapt in ways that facilitate efficient, sustained human-to-human transmission," according to a joint statement on Thursday from the World Health Organization and the United Nations Food and Agriculture Organization.

http://www.thepoultrysite.com/poultrynews/38363/stronger-precautions-urged-for-bird-flu/



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Posted By: jacksdad
Date Posted: March 25 2017 at 10:42am
Originally posted by Albert Albert wrote:

"Experts agree that it is not a question of if, but when the virus will adapt in ways that facilitate efficient, sustained human-to-human transmission," according to a joint statement on Thursday from the World Health Organization and the United Nations Food and Agriculture Organization.

http://www.thepoultrysite.com/poultrynews/38363/stronger-precautions-urged-for-bird-flu/



That is a really disconcerting statement, given how emphatic it is in predicting H2H transmission. To see one of those agencies come out and issue a warning like this is pretty significant - that they're both in agreement is very worrying.




-------------
"Buy it cheap. Stack it deep"
"Any community that fails to prepare, with the expectation that the federal government will come to the rescue, will be tragically wrong." Michael Leavitt, HHS Secretary.


Posted By: Albert
Date Posted: March 26 2017 at 1:52am
Not good news at all.  This bug is definitely rapidly changing.  You may have called it JD, on the 100th anniversary since 1918.  Of course it probably now also has the capability of mixing much easier with h1n1, for the 1918 replay.   Or maybe it will just be a flat h7n9 pandemic, who knows, but this pattern is getting concerning - and now a joint statement to prepare for sustained human transmission?  

The transmission is increasing along with the mortality rate.  The mutation models vs. ease of transmission apparently were not correct over the years.  The 1918 flu also mutated to a more severe form. 

I believe the 1918 pandemic flu began in May?  

On another note, the worst news is that Tamiflu and anti-virals are going to be useless with this one. 


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Posted By: Albert
Date Posted: March 26 2017 at 2:34am
Stronger precautions are urged for bird flu


By Wang Xiaodong | China Daily USA | Updated: 2017-03-24 07:31

Two international organizations have stressed the high possibility of human-to-human transmission of the H7N9 virus, which saw the biggest outbreak in China over the past winter since first being reported in China in 2013.

The organizations urged the Chinese government to take more precautionary measures to prevent a possible bird flu epidemic.

"Experts agree that it is not a question of if, but when the virus will adapt in ways that facilitate efficient, sustained human-to-human transmission," according to a joint statement on Thursday from the World Health Organization and the United Nations Food and Agriculture Organization.

There was no evidence of sustained human transmission of the virus, but H7N9 has continued to change, the statement said.

Researchers recently identified two separate genetic lineages of H7N9, adding complications to the making of candidate virus vaccines, the first step in developing vaccines for birds and humans, it said.

The University of Hong Kong said on Wednesday that its researchers had identified a mutation in H7N9 avian flu that can enhance its ability to infect humans.

In February, the Chinese Center for Disease Control and Prevention said H7N9 had mutated to a new strain in South China, which did not affect the virus's ability to spread between humans but made it more dangerous among poultry.

China reported 352 human cases of H7N9 in the first two months of the year, resulting in 140 deaths, according to the National Health and Family Planning Commission.

"We have a short window of time - before the next seasonal outbreak in winter - to get ahead of the virus and prevent a SARS-type event," the joint WHO-UNFAO statement said, adding that during this short window, policymakers need to have immediate intervention steps ready to control the virus.

"This may involve a mix of market closures and poultry vaccinations as a requirement for market access," it said, adding that over 90 percent of reported cases involved individuals in direct contact with live poultry or a market selling live poultry.

Once a problem is identified, the intervention steps need to be fully implemented before the next seasonal peak, which is during the Chinese New Year holiday, it said.

Chinese authorities have taken measures since winter, such as closing live poultry markets, to control and prevent the virus.

Live poultry markets in Changsha, the capital of Hunan province, were suspended for three weeks beginning March 17, according to the city's health commission.

In Anhui province, most cities and counties have closed live poultry markets since February, local media reported.

The WHO-UNFAO statement said China needs to intensify enforcement of the closure of live poultry markets to eliminate the threat.

Sporadic cases of bird flu may last until late April, according to the China CDC. Currently, there is no vaccine for the virus, but several Chinese companies have received approval from the China Food and Drug Administration for clinical trials of vaccines.

Premier Li Keqiang said in February that China will promote business models that feature large-scale farming, centralized slaughtering and cold-chain transportation, including the keeping and selling of poultry in chilled conditions, to prevent similar poultry-related disease outbreaks.

wangxiaodong@chinadaily.com.cn

http://usa.chinadaily.com.cn/epaper/2017-03/24/content_28666643.htm


Comment:  A Sars-type event would indicate it's about to spread slowly via limited h2h transmission.




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Posted By: jacksdad
Date Posted: March 26 2017 at 10:05am
Please don't let me be right about this one Shocked

H1N1 first showed up in the early part of 1918 - possibly as early as January. I can only assume it survived the transition period between the first and second waves in the colder temperatures of the Southern Hemisphere's winter. Hopefully H7N9 will stay geographically pinned down in China and not head south as their flu season comes to an end.




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"Buy it cheap. Stack it deep"
"Any community that fails to prepare, with the expectation that the federal government will come to the rescue, will be tragically wrong." Michael Leavitt, HHS Secretary.


Posted By: Albert
Date Posted: March 26 2017 at 10:23am
There is a reason why first reports from U.S. Health Officials stated the latest mutations were not more infectious, until the Hong Kong researchers announced it.  The same reason why they can't determine if H7N9 is in fact resistant to antivirals.  Quite simply, China is not releasing samples, and they haven't since 2013.  The only info the world gets is spoon-fed information from China, and we all know how much they can be trusted.


There have also been reports that some of the viruses may no longer be susceptible to oseltamivir — sold as Tamiflu — and other flu drugs of the same class. There are few drugs that treat influenza, and if H7N9 became resistant to these drugs, it would be a highly unwelcome development. But the CDC’s Davis said so far it appears that the cases of resistance have involved hospitalized people who were taking the drugs for protracted periods.

Resistance can evolve during treatment, but resistance among viruses that haven’t yet been exposed to the drug would be more alarming, he and Jernigan said.

Scientists at the CDC would like to test virus samples from China to ensure that the flu drugs are still effective. But a disease diplomacy problem is getting in the way of that work.

While China has been reporting cases and sharing the genetic sequences of viruses, it has not shared actual virus samples with the United States since the early days of the H7N9 outbreak, Jernigan said.

Thanks to developments in synthetic biology, genetic sequences can be used to make sample viruses that can tell scientists a lot about how a virus behaves. Still, viral samples would be useful. “Synthetic biology is amazing. But it still takes time,” said Davis.

Jernigan said scientists at the China CDC collaborate openly with their international colleagues. But a green light to share viruses would need to come from other parts of the government. He said efforts are underway to try to open those doors.

https://www.statnews.com/2017/02/28/bird-flu-surge/


Comment:  Only response to this about China is, A**holes.  Excuse my French.


 


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Posted By: Eight
Date Posted: March 27 2017 at 5:23am
Honestly if China keeps stonewalling the CDC they need to simply make recombinants on their own. This is quite feasible, but perhaps a bit pricey--nothing the CDC can't handle. And of course China deserves an obligatory middle finger for witholding samples. It goes against standard scientific protocol and all logic. 

As far as mortality and transmission, I was a bit wrong when I remembered this paper in question, although it is with H7N1:

https://www.ncbi.nlm.nih.gov/pubmed/24696487

Verdict: Low sample size, but no apparent decrease in pathogenicity required for airborne Ferret-to-Ferret transmission. 

Thinking it over, I doubt we'd see attenuation in humans if we don't even have substantial H2H. We are probably just observing either strain differences or statistical artifacts. Neither of which is comforting since we're still looking at Smallpox-level mortality.


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Such a beautiful number, eight.


Posted By: Guests
Date Posted: June 04 2017 at 4:12am
I have congenital and acquired immunity to influenza. I get infected like an ordinary person, but I get sick for 2-4 days or not at all. Age 39 years sex male I suggest to make a vaccine against the flu from my blood. But I suggest that the patient make a vaccine from the components of my blood. Namely from an immunoglobulin. Muslim. In the Holy Quran does not say that you can not make a vaccine from the blood of a Muslim in emergency situations. Allah Almighty will allow me to make the vaccine out of my blood. Muslim. 3 times a day I take taharat in cold tap water, and 2 times in icy water from the column, my feet once a day but in warm water, and this is micro hardening. Congenital immunity: I do not suffer from diabetes mellitus, other type of diabetes. I drink a lot of water. IC - Well, someone should get it to the lab, take a sample and run the sequence. Then he will know for sure. If there are antibodies in there - the world, you may need them.

And also who should get it in the laboratory work to take a sample and follow the sequence. Then he will know for sure. If antibodies are available in the world, they may be required. According to American doctors. HELP me to prove my immunity. I have only 4 years to live, I can die in a few hours. I have a disease of Olivia ponto cerebral degeneration with cerebellar atrophy. One of the manifestations of this disease is not controlled by the saliva, the discharge is due to this constantly pressurized with food intake, and when combined with non-diabetes by the end of the day the saliva becomes tight and I press when I sit quietly. This continues until I take a cure for not diabetes. And I also have a shaky gait and double vision in my eyes. So I can get under the car. But the state of health is constantly deteriorating. The Ministry of Health of the Russian Federation and Almetyevsk doctors do not want to conduct home-based research, so I have to conduct them myself. I got sick with the flu: on Saturday the temperature was 37.2, on Sunday 37.3 there were no symptoms, I went to the mosque, on Monday the temperature was 36.6. And on Tuesday the complication of a severe runny nose began, the temperature went 37.3 to the mosque, a strong cough was added to the severe cold on Wednesday, 37 went to the mosque, the rhinitis passed on Thursday, there was only a mild cough. The temperature 37.5 stayed at home, and Friday was fresh as a cucumber. Before the mosque 150 meters on the street the temperature is from 0 to +5 degrees. Mom was scared that I had a flu 5 days with such a small temperature. On Thursday, they went to the hospital and prescribed medication. All charges against me are far-fetched. I only have immunity against the flu. Let me become the last human defense line against the flu. Immunity is proven through the Internet. Immunity is good who drinks water from 2 to 3 liters a day, and I drink from 3 to 5 liters a day. And plus this I do micro-hardening







Posted By: Albert
Date Posted: June 04 2017 at 2:30pm
Rishat.   You have been doing this for 5 years here, and you have been advised that JD's blood is superior.    But at my age now, anything could be possible.  Who knows.  

Ришат. Вы делаете это в течение 5 лет здесь, и вам сообщили, что кровь JD выше. Но в моем возрасте теперь все возможно. Кто знает.


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Posted By: jacksdad
Date Posted: June 04 2017 at 3:08pm
The very mention of my blood can kill the influenza virus. Beat that.




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"Buy it cheap. Stack it deep"
"Any community that fails to prepare, with the expectation that the federal government will come to the rescue, will be tragically wrong." Michael Leavitt, HHS Secretary.


Posted By: CRS, DrPH
Date Posted: June 04 2017 at 9:49pm
Originally posted by jacksdad jacksdad wrote:

The very mention of my blood can kill the influenza virus. Beat that.


I'm sold!  Send me as much as you can, as quickly as possible, JD!  LOL


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CRS, DrPH


Posted By: Albert
Date Posted: June 05 2017 at 6:58am
lol.

Rishat, you can be backup and 2nd inline after JD.  Tongue


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Posted By: Albert
Date Posted: June 05 2017 at 7:02am
Sitting time bomb.  Seems like h7n9 will lead to the next pandemic.  The question is, when? A year maybe.  Who knows.   Each winter this one keeps mutating and not many more step until human adaptation, it would seem.


Scary Bird Flu Mutations Could Lead to Worst Pandemic in History


Leading scientists in the field of deadly flu epidemics are worried about what could be the granddaddy of them all, and say it could be right around the corner. 

They're talking about the bird flu, also known as H7N9. Experts say it could be as bad as, or even more severe, than the worst global pandemic in recorded history. That was the Spanish flu outbreak of 1918, which killed an estimated 40 million people. That flu also originated in birds.

Alarms began sounding in the medical research community when scientists observed the bird flu was rapidly mutating and killing chickens in China. That's scary because, until now, when chickens got the bird flu it was so mild, the chickens generally did not die from it. Now, however, the virus is far stronger and deadlier. Not only are chickens dying, they're dying fast, sometimes in just one day, and they're spreading it to other fowl. 

The bird flu outbreak among chickens is ominous for humans. 

"It makes us queasy," former global director of the World Health Organization's Influenza Program, Keiji Fukuda, told http://www.npr.org/sections/goatsandsoda/2017/04/11/523271148/why-chinese-scientists-are-more-worried-than-ever-about-bird-flu" rel="nofollow -

Oftentimes flu viruses that circulate among animals are passed to people. That's already happening in China with the H7N9 bird flu strain. When people catch the bird flu from chickens, about a third of the humans die. It's already killed nearly 200 people this flu season (September to March). That's more deaths than in any single season since when it was first discovered in humans four years ago. 

When it comes to containing flu outbreaks, the smartest virologists in the world are stumped by this one. Guan Yi who was instrumental in minimizing the Swine flu and SARS is pessimistic about this aggressive bird flu, mainly because it is changing so fast. "We're trying our best, but we still can't control this virus," He said, "It's too late for us to eradicate it."

http://www1.cbn.com/cbnnews/health/2017/april/Scary-Bird-Flu-Mutations-Could-Lead-to-Worst-Pandemic-in-History



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Posted By: Albert
Date Posted: June 06 2017 at 6:42am
Originally posted by Rishat Rishat wrote:

В статье массовое производство иммуноглобулина возможно производство вакцины из крови

К счастью, никто не сделает из вашей крови вакцину моего друга. Никто не поверит, и этого не произойдет. Еще слишком рано делать вакцину до тех пор, пока она не мутируется. Может быть, вы останетесь единственным, кто выживет после следующей пандемии.   Big smile


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Posted By: jacksdad
Date Posted: June 06 2017 at 7:53am
Originally posted by Rishat Rishat wrote:

I got sick with the flu: on Saturday the temperature was 37.2, on Sunday 37.3 there were no symptoms, I went to the mosque, on Monday the temperature was 36.6. And on Tuesday the complication of a severe runny nose began, the temperature went 37.3 to the mosque, a strong cough was added to the severe cold on Wednesday, 37 went to the mosque, the rhinitis passed on Thursday, there was only a mild cough. The temperature 37.5 stayed at home, and Friday was fresh as a cucumber.


You had flu-like symptoms and a low grade fever that persisted for almost a week? That's not super immunity - that's exactly what happens when the rest of us get sick. Sorry Rishat, but you're no different from the rest of us.

У вас были симптомы гриппа и низкая лихорадка, которые сохранялись почти неделю? Это не супер иммунитет - это именно то, что происходит, когда все остальные болеют. Прости, Ришат, но ты ничем не отличаешься от остальных.




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"Buy it cheap. Stack it deep"
"Any community that fails to prepare, with the expectation that the federal government will come to the rescue, will be tragically wrong." Michael Leavitt, HHS Secretary.


Posted By: Albert
Date Posted: June 06 2017 at 1:32pm
Rishat, you're a healthy guy.  I know many people who only get sick for a few days, as JD pointed out.  I'm not one of them.   Your intentions are good my friend. 

My mother is 75 and has NEVER been sick in her entire life.  Not even a cold, ever.  Extremely healthy. 

Glad you are feeling better, and will let you know when vaccine time arrives, and hope that time never does arrive. :)

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Ришат, ты здоровый парень. Я знаю многих людей, которые только болеют в течение нескольких дней, как указал JD. Я не из них. Ваши намерения хороши моим другом.

Моя мать 75 лет и НИКОГДА не болела за всю свою жизнь. Даже не холодно, никогда. Очень здорово.

Рад, что вы чувствуете себя лучше, и сообщите вам, когда придет время вакцины, и надейтесь, что время не придет. :)







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Posted By: carbon20
Date Posted: June 12 2017 at 2:08pm

FACTBOX-China bird flu death toll hits 37 in May

 By  http://www.nasdaq.com/author/Reuters" rel="nofollow - Reuters

BEIJING, June 12 (Reuters) - China reported another 37 fatalities from H7N9
bird flu in May, the government said on Monday, taking the death toll since
October to at least 268.
    China reported as many as 108 deaths from the same virus in the last three
months, spurring further concerns about the spread of the deadly virus,
according to data from the National Health and Family Planning Commission.
    The death toll tends to drop towards the end of winter.
    Chinese disease control experts warned the public to stay alert for H7N9
avian flu and stay away from live poultry, with the commission saying new cases
of human infection remained at a low level in the last two weeks of May,
according to a statement released on its website earlier this month.
    The National Health and Family Planning Commission did not disclose the
location of fatalities or infections.
    The H7N9 virus is likely to strike in winter and spring, and farmers have in
the recent years ramped up measures such as cleaning regimes to prevent the
disease. China has confirmed five bird flu outbreaks among poultry this winter,
which has led to the culling of more than 175,000 birds.
    China, the world's third-largest producer of broiler chickens and the
second-biggest consumer of poultry, has also closed some live poultry markets
after people and chickens were infected by the avian flu strains.
    Here is a table for the poultry and human bird flu cases reported in China,
including the Chinese territories of Hong Kong and Macau:

 Location    Birds     Birds    Virus      Details
             infected  culled   strain
 Total       63,338    175,308  H5N6
 Xinjiang    16,000    55,903   H5N6       Strain confirmed in
                                           Yining, a city of
                                           500,000 people
                                           [nL4N1EM2AF]
 Sichuan     13,000    38,000   H5N6       Strain confirmed in
                                           Deyang, a city of 3.5
                                           million people
 Gansu       30,000    77,172   H5N6       Strain confirmed in a
                                           district in Jinchang,
                                           a city of 470,000
                                           people
 Hubei       4,338     2,166    H5N6       Strain confirmed in
                                           Xiaochang, a city of
                                           4.8 million people
 Hunan                 2,067    H5N6       Strain confirmed on a
                                           goose farm in
                                           Yuanjiang, a city of
                                           760,000 people
 Location    People    Deaths   Virus      Details
             Infected
 Total       713*      268*     H7N9

 Guangdong   35        10       H7N9       Province reported 14
                                           infections in Dec and
                                           21 in Jan. Warned
                                           that about 30 percent
                                           of live poultry
                                           markets infected with
                                           H7N9. [nL4N1FW06M]
                                           Guangzhou suspended
                                           markets for some days
                                           through March
                                           [nL4N1EZ2WU][nL4N1EV3
                                           OP]
 Hunan       20        5        H7N9       Authorities closed
                                           live poultry markets
                                           in several cities
                                           including provincial
                                           capital Changsha
                                           [nL4N1FS35E]
 Zhejiang    35                 H7N9       Provinces ordered all
                                           live poultry markets
                                           shut [nL4N1FW06M]
 Jiangsu     4                  H7N9       Three cities -
                                           Suzhou, Wuxi and
                                           Changzhou - suspended
                                           live poultry trade
                                           after neighbouring
                                           provinces infected
                                           [nL4N1EK030]
 Anhui       5         2        H7N9       The province shut
                                           some livestock
                                           markets and stepped
                                           up sterilisation
                                           [nL4N1EI1UP]
 Fujian      1                  H7N9       [nL4N1EH18R]
 Jiangxi     6                  H7N9       [nL4N1ER01W]
 Guizhou     2                  H7N9       [nL1N1ET02I]
 Shanghai    4                  H7N9       [nB9N1EG028]

 Shandong    2         1        H7N9       [nL4N1EV3OP]
 Henan                 2        H7N9

 Beijing     1                  H7N9
 Yunan                 1        H7N9
 Guangxi     3         1        H7N9
 Hong Kong   3         2        H7N9       [nL4N1EP05P]
                                           [nL4N1EW1LA]
 Macau       2                  H7N9       [nL4N1EF1X4]
 * China's government did not specify where each human infection
 case took place.


 (Reporting by Hallie Gu and Josephine Mason; Editing by Sherry Jacob-Phillips)
 (( mailto:Hallie.Gu@thomsonreuters.com" rel="nofollow - Hallie.Gu@thomsonreuters.com ; +86 10 6627 1250; Reuters Messaging:
 mailto:hallie.gu.thomsonreuters.com@reuters.net" rel="nofollow - hallie.gu.thomsonreuters.com@reuters.net ))

Keywords: HEALTH BIRDFLU/CHINA (FACTBOX)


Read more:  http://www.nasdaq.com/article/factboxchina-bird-flu-death-toll-hits-37-in-may-20170612-00374#ixzz4jpAoOaI7" rel="nofollow - http://www.nasdaq.com/article/factboxchina-bird-flu-death-toll-hits-37-in-may-20170612-00374#ixzz4jpAoOaI7


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12 Monkeys...............
1995 ‧ Science fiction film/Thriller ‧ 2h 11m a must for AFT


Posted By: Guests
Date Posted: June 12 2017 at 10:59pm
I have congenital and acquired immunity to influenza. I get infected like an ordinary person, but I get sick for 2-4 days or not at all. Age 39 years old male I suggest to make a vaccine against the flu from my blood. But I suggest that the patient make a vaccine from the components of my blood. Namely from an immunoglobulin. Muslim. In the Holy Quran does not say that you can not make a vaccine from the blood of a Muslim in emergency situations. Allah Almighty will allow me to make the vaccine out of my blood. Muslim. 3 times a day I take taharat in cold tap water, and 2 times in icy water from the column, my feet once a day but in warm water, and this is micro hardening. Congenital immunity: I do not suffer from diabetes mellitus, other type of diabetes. I drink a lot of water. IC - Well, someone should get it to the lab, take a sample and run the sequence. Then he will know for sure. If there are antibodies in there - the world, you may need them.

And also who should get it in the laboratory work to take a sample and follow the sequence. Then he will know for sure. If antibodies are available in the world, they may be required. In the opinion of American doctors. HELP me to prove my immunity. I have only 4 years to live, I can die in a few hours. I have a disease of Olivia ponto cerebral degeneration with cerebellar atrophy. One of the manifestations of this disease is not controlled by the saliva, the discharge is due to this constantly pressurized with food intake, and when combined with non-diabetes by the end of the day the saliva becomes tight and I press when I sit quietly. This continues until I take a cure for not diabetes. And I also have a shaky gait and double vision in my eyes. So I can get under the car. But the state of health is constantly deteriorating. The Ministry of Health of the Russian Federation and Almetyevsk doctors do not want to conduct home-based research, so I have to conduct them myself. I got sick with the flu: on Saturday the temperature was 37.2, on Sunday 37.3 there were no symptoms, I went to the mosque, on Monday the temperature was 36.6. And on Tuesday the complication of a severe runny nose began, the temperature went 37.3 to the mosque, a strong cough was added to the severe cold on Wednesday, 37 went to the mosque, the rhinitis passed on Thursday, there was only a mild cough. The temperature 37.5 stayed at home, and Friday was fresh as a cucumber. Before the mosque 150 meters on the street the temperature is from 0 to +5 degrees. Mom was scared that I had a flu 5 days with such a small temperature. On Thursday, they went to the hospital and prescribed medication. All charges against me are far-fetched. I only have immunity against the flu. Let me become the last human defense line against the flu



Posted By: Eight
Date Posted: June 13 2017 at 7:18am
Rishat, you can't have congenital immunity to any disease that's immunoglobulin based. All of that would be acquired and simply means you have an adaptive immune system like the rest of us.

If it was immunoglobulin based, what makes you think resistance to H1N1 or H3N2 would carry over to H7N9, a very, very different virus? Remember, immunoglobulin is very specific and not promiscuous. 

Also, how do you know you had the flu? Was it confirmed by a test kit?

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Such a beautiful number, eight.


Posted By: jacksdad
Date Posted: June 13 2017 at 11:34am
Rishat - apparently you don't have immunity to the flu because what you described is someone getting sick with the flu. You had a temperature, a cough, runny nose, and your mom was worried about you. All symptoms of the flu. People with immunity don't get any symptoms. You don't have super-immunity, dude.

Ришат - видимо, у вас нет иммунитета к гриппу, потому что вы описали кого-то, болеющего гриппом. У тебя была температура, кашель, насморк, и твоя мама беспокоилась о тебе. Все симптомы гриппа. Люди с иммунитетом не получают никаких симптомов. У вас нет супер-иммунитета, чувак.





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"Buy it cheap. Stack it deep"
"Any community that fails to prepare, with the expectation that the federal government will come to the rescue, will be tragically wrong." Michael Leavitt, HHS Secretary.


Posted By: carbon20
Date Posted: June 13 2017 at 2:27pm
why bother even interacting......................

he maybe immune to the flu...................

but the mental damage has been EXTENCIVE!!!!!!!!!!!!!.............


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12 Monkeys...............
1995 ‧ Science fiction film/Thriller ‧ 2h 11m a must for AFT


Posted By: EdwinSm,
Date Posted: June 13 2017 at 9:37pm
Originally posted by Albert Albert wrote:

My mother is 75 and has NEVER been sick in her entire life.  Not even a cold, ever.  Extremely healthy. 


When are you going to cash in and sell her blood on this forum? Big smileEvil SmileCensored


Posted By: jacksdad
Date Posted: June 14 2017 at 2:34am
LOLLOL





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"Buy it cheap. Stack it deep"
"Any community that fails to prepare, with the expectation that the federal government will come to the rescue, will be tragically wrong." Michael Leavitt, HHS Secretary.


Posted By: Medclinician
Date Posted: June 14 2017 at 3:25pm
Originally posted by Albert Albert wrote:

Not good news at all.  This bug is definitely rapidly changing.  You may have called it JD, on the 100th anniversary since 1918.  Of course it probably now also has the capability of mixing much easier with h1n1, for the 1918 replay.   Or maybe it will just be a flat h7n9 pandemic, who knows, but this pattern is getting concerning - and now a joint statement to prepare for sustained human transmission?  

The transmission is increasing along with the mortality rate.  The mutation models vs. ease of transmission apparently were not correct over the years.  The 1918 flu also mutated to a more severe form. 

I believe the 1918 pandemic flu began in May?  

On another note, the worst news is that Tamiflu and anti-virals are going to be useless with this one. 


They all are mutating Albert. It's not just bird flu, but the new strains of that could go Pandemic. I still think it will be a genetically engineered bug from the U.S., Russia, or even one of the unstables - such as North Korea.

Also I think we are headed for a triple play - as in - three Pandemics at once. I had posted years ago that bacteria and viruses can communicate - at least work together. We have seen some very interesting grouping in outbreaks.  H5N9 is yet another contestant - but I am still thinking Prions or Henta - all can be genetically engineered and much improved in the worse ways.

Med


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"not if but when" the original Medclinician


Posted By: Albert
Date Posted: June 14 2017 at 7:08pm
Hello there Med, speaking of engineered or lab accident, I'm still baffled with all of the h7n9 cases to date, it still has failed to infect a non- Asian or to spread outside of China with a human case.    It also appears to be mutating quite a bit faster than the others we've ever seen.   Let's hope the 6th wave next winter isn't the big one, although they do seem to pick up steam with each wave either way, so who knows.       

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https://www.facebook.com/Avianflutalk


Posted By: carbon20
Date Posted: June 15 2017 at 2:24am
H1N1 is mutating in India, funny that in the Two most populated countries we seeing flu viruses change before our eyes,not funny really just that the virus has more hosts,more changes to the R.N.A,when the Two collide, h1n1 and h7n9, can't be far away......

12 MONKEYS



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12 Monkeys...............
1995 ‧ Science fiction film/Thriller ‧ 2h 11m a must for AFT


Posted By: Technophobe
Date Posted: June 15 2017 at 3:23am
All types of flu mutate all the time, Med.  You are right that is a danger and a worry.  

However, luckily for us, most mutations are harmless, though it is just a matter of time before one turns truly nasty.  But, it is highly unlikely that all three will mutate catastrophically (from our viewpoint) at the same time.


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Absence of proof is not proof of absence.


Posted By: Guests
Date Posted: June 18 2017 at 3:23am
But you missed the moment when I had 3 complications


Posted By: Technophobe
Date Posted: June 18 2017 at 5:09am
Complications, however many, stem from the same root illness.  This is almost an inviolate law in medicine.  That is profoundly different from 3 separate diseases circulating simultaneously, all of which have mutated toward the same point.  The first is an odds on favorite, the latter many trillions to one against.  It is not impossible, but less likely than an invasion, at precicely 15.47 next Tuesday, by two separate alien races, who then fight each other.

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Absence of proof is not proof of absence.


Posted By: Guests
Date Posted: June 18 2017 at 6:22am
This complication, a person with the flu, go outside with a temperature of 0 to +5This complication, a person with the flu, go outside with a temperature of 0 to +5


Posted By: jacksdad
Date Posted: June 18 2017 at 8:26am
Rishat - I'll try to explain this again because we're all getting tired of you posting the same nonsense over and over.

YOU BECAME SICK JUST LIKE EVERYBODY ELSE SO YOU DON'T HAVE SUPER IMMUNITY. Got it?

You had a runny nose, cough and a low grade fever for almost a week. Those are symptoms of a flu-like illness. Not everybody gets a full fever, but you still caught it - just like we all do. You don't have super immunity and never did. Sorry to be the one to break the news to you, but you're not special. Just a regular human being like the other seven billion and change.

Welcome to the club.







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"Buy it cheap. Stack it deep"
"Any community that fails to prepare, with the expectation that the federal government will come to the rescue, will be tragically wrong." Michael Leavitt, HHS Secretary.


Posted By: Guests
Date Posted: June 18 2017 at 11:33am
.I can prove my immunity. Inviting immunology. I suggest you invite an immunologist


Posted By: jacksdad
Date Posted: June 18 2017 at 11:51am
Not my job. It's up to you to prove it. My job is to delete the multiple posts you put up each day where you either make the same unproven claims over and over, or type gibberish to get attention.

All I'm seeing is a guy that just described catching the flu telling me he has super immunity to it. Makes no sense whatsoever. A severe flu virus would kill you as fast as any of us.

No buyers here, Rishat.






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"Buy it cheap. Stack it deep"
"Any community that fails to prepare, with the expectation that the federal government will come to the rescue, will be tragically wrong." Michael Leavitt, HHS Secretary.


Posted By: Technophobe
Date Posted: June 18 2017 at 12:03pm
If you can it would be a miracle because you are .............................................................................  normal, ORDINARY, usual, just like everyone else, unexeptional, average, common, standard, undestinguished, humdrum, bland, prosaic, lacklustre,  everyday, normal, run of the mill, pedestrian, mediocre, noteworthy, bog standard.    Just like everyone else.  

Your immune system behaves like the immune system of every other normal healthy person.  It is not unusual.  It is not exceptional.  It is not superhuman.  It is not in any way different from mine.  There is nothing about it which singles it out as worthy of further study.  If the research money were spent on investigationg immune systems like yours, we would lynch the scientists for wasting our tax dollars on fripperies.

Если бы вы могли, это было бы чудом, потому что вы ... ....................................... нормальный, обычный, обычный, как и все остальные, Неспециализированный, средний, общий, стандартный, незаметный, скучный, мягкий, прозаический, тусклый, повседневный, нормальный, пробег мельницы, пешеходный, посредственный, заслуживающий внимания, стандарт болота. Как и все еще.

Ваша иммунная система ведет себя как иммунная система любого другого нормального здорового человека. Это не редкость. Это не исключение. Это не сверхчеловек. Это ничем не отличается от моего. В этом нет ничего, что выделяло бы его как достойное дальнейшего изучения. Если бы исследовательские деньги были потрачены на исследование иммунных систем, подобных вашим, мы бы линчевали ученых за то, что они бросали наши налоговые доллары на фриперсы. Вы НОРМАЛЬНО, ПРАВИЛЬНО И ОБЫЧНО.


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Absence of proof is not proof of absence.


Posted By: jacksdad
Date Posted: June 18 2017 at 12:17pm
Yep. What she said Thumbs Up




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"Buy it cheap. Stack it deep"
"Any community that fails to prepare, with the expectation that the federal government will come to the rescue, will be tragically wrong." Michael Leavitt, HHS Secretary.


Posted By: jacksdad
Date Posted: June 18 2017 at 1:10pm
Sorry Rishat. The rule around here is you call your own immunologist. We're pretty strict on that one.






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"Buy it cheap. Stack it deep"
"Any community that fails to prepare, with the expectation that the federal government will come to the rescue, will be tragically wrong." Michael Leavitt, HHS Secretary.


Posted By: Technophobe
Date Posted: June 18 2017 at 1:29pm
This is an information website, Rishat.  

We have no money for immunologists.  We do not fund research.  If we did: you would not be top of the list.  You are just too much like the rest of us.


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Absence of proof is not proof of absence.


Posted By: Technophobe
Date Posted: June 18 2017 at 1:32pm
So what?

We are not going to fund/find/fudge one for you.  You count as a person, but not as a case study.




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Absence of proof is not proof of absence.


Posted By: carbon20
Date Posted: June 18 2017 at 4:20pm
needs a mental hospital,

got the perfect place .............

The White House............Tongue


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12 Monkeys...............
1995 ‧ Science fiction film/Thriller ‧ 2h 11m a must for AFT


Posted By: Technophobe
Date Posted: June 18 2017 at 4:33pm
LOL

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Absence of proof is not proof of absence.


Posted By: Guests
Date Posted: June 19 2017 at 7:51am
.Tomorrow I will prove that I'm not crazy


Posted By: Guests
Date Posted: June 20 2017 at 8:45am
Psychiatric examination will be tomorrow June 21


Posted By: Albert
Date Posted: June 20 2017 at 4:17pm
don't worry Rishat.  The Doctors are wrong my friend.  You worry too much.

JD?


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https://www.facebook.com/Avianflutalk


Posted By: jacksdad
Date Posted: June 21 2017 at 1:15am
My doctor's crazy. He won't let any of us have sharp objects in here. And if I have to complain about the padding on the walls not being cleaned one more time...



-------------
"Buy it cheap. Stack it deep"
"Any community that fails to prepare, with the expectation that the federal government will come to the rescue, will be tragically wrong." Michael Leavitt, HHS Secretary.


Posted By: jacksdad
Date Posted: June 21 2017 at 2:34am
Rishat, I'm not doubting your mental status - all I'm asking is you stop posting the same thing over and over again. We get it, but you've been doing this all over the internet for quite some time now - a search for "Rishat super immunity" shows just how busy you've been.

I'm sure you're sincere, but in the past few days I've deleted maybe 20 of your posts that were nothing more than "Aaaa", Bbbb", or some other random combination of letters. I know some of the other moderators are doing the same, or hiding them. Please respect the other members on this forum and post in a mature manner. That's all we're asking.




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"Buy it cheap. Stack it deep"
"Any community that fails to prepare, with the expectation that the federal government will come to the rescue, will be tragically wrong." Michael Leavitt, HHS Secretary.


Posted By: Technophobe
Date Posted: June 21 2017 at 2:50am
Rishat, I second every word of that plea.....
Please stop posting nnn, ttt, sss or any variations on that theme.




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Absence of proof is not proof of absence.


Posted By: Guests
Date Posted: June 23 2017 at 8:08am
The head physician was scared to do me a psychiatric examination. Because I'm healthy. This is a violation of human rights. And to that already I was put under police supervision I ask you to send me a psychiatrist's doctor


Posted By: Guests
Date Posted: June 28 2017 at 4:46am
But I am completely mentally healthy. Sorry for the transition from English to Russian Google interpreter incorrectly translated and I had to send an article in Russian


Posted By: Guests
Date Posted: June 30 2017 at 3:25am
I want to help people in the treatment of influenza. Production of the vaccine will take a few months which in a pandemic can be fatal. And I, in turn, propose the production of vaccines from immunoglobulin. Which will take several days. If you are not interested, let me know. And if you are interested, then come to Almetyevsk


Posted By: Albert
Date Posted: June 30 2017 at 4:32pm
Hi Rishat, you may find a problem posting on the forum, but since you're reading this,  you are still able to post in the dungeon forum located http://www.avianflutalk.com/the-dungeon_forum476.html" rel="nofollow - here.   

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https://www.facebook.com/Avianflutalk


Posted By: jacksdad
Date Posted: July 01 2017 at 6:43am
Originally posted by Albert Albert wrote:

Hi Rishat, you may find a problem posting on the forum, but since you're reading this,  you are still able to post in the dungeon forum located http://www.avianflutalk.com/the-dungeon_forum476.html" rel="nofollow - here.   


Sent to the dungeon. That'll work Thumbs Up




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"Buy it cheap. Stack it deep"
"Any community that fails to prepare, with the expectation that the federal government will come to the rescue, will be tragically wrong." Michael Leavitt, HHS Secretary.


Posted By: Technophobe
Date Posted: July 01 2017 at 10:38am
Thanks, Boss.  It was getting tiresome.

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Absence of proof is not proof of absence.


Posted By: Albert
Date Posted: July 01 2017 at 2:27pm
Rishat - you can still post http://.www.avianflutalk.com/the-dungeon_forum476.html" rel="nofollow - here.   You are not banned. 

Thanks Maggie for your patience.  


Posted By: iwrote1
Date Posted: July 02 2017 at 4:44am
That's pretty cool news about Rishat. I don't like to brag, but although I'm not immune to viruses, I do have the ability to fly. No seriously, it's true. It was around my 18th birthday that I first discovered that I had this ability, when I flew from Florida to Pennsylvania. It was incredible. Since that experience I've flown several other times, sometimes taking my wife along for the ride. In fact, I'm planning on flying over the 4th of July weekend, as long as my reservations don't get cancelled.  ;-)


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The Pandemic Preparedness Guide


Posted By: Technophobe
Date Posted: July 02 2017 at 12:30pm
LOLClap

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Absence of proof is not proof of absence.



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