A Flu 0f... . relatively low virulence?

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   . 

REPORT TO THE PRESIDENT
ON U.S. PREPARATIONS FOR
2009-H1N1 INFLUENZA

Executive Office of the President
President’s Council of Advisors on
Science and Technology
August 7, 2009

http://www.whitehouse.gov/assets/documents/PCAST_H1N1_Report.pdf

 (hoping for funding of one time Universal Flu Vaccine)

...$5.8 billion contingent appropriation. 

After spending an initial $1.85 billion on procurement of vaccines, 

expansion of surveillance activities, 

and preparation for a possible immunization campaign, 

on July 16 the President designated an additional $1.825 billion 

as emergency funds to support additional measures 

related to influenza vaccination efforts, 

leaving $3.975 billion in reserve as contingency funds.

and .. 

A major determinant of virus virulence, the expression of a protein called 

PB1-F2 

is absent in the 2009-H1N1 virus , 

{which was known to cause cell death and was found in viruses responsible 

for influenza pandemics of 1918-19 (H1N1), 1957 (H2N2), and 1968 (H3N2))

Accounting for the relatively low virulence of  the 2009-H1N1 virus.
....................................................................................................................

Is the expression of  protein PB1-F2 expected to appear this winter?
...................................................................................................................

 Of interest is the recent finding that the H1N1 virus currently lacks the protein PB1-F2, 

which is believed to be an important determinant of virulence and lethality in influenza 

viruses (Osterhaus, A. and Garau, J., 2009). 
............

http://science.thomsonreuters.com/pharma/h1n1/

.........................

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Mary008 Members Profile Send Private Message Find Members Posts Add to Buddy List V.I.P. Member Joined: June 22 2009 Status: Offline Points: 5769	Post Options Post Reply Quote Mary008 Thanks(0) Quote Reply Topic: A Flu 0f... . relatively low virulence? Posted: August 26 2009 at 7:06pm
	. REPORT TO THE PRESIDENT ON U.S. PREPARATIONS FOR 2009-H1N1 INFLUENZA Executive Office of the President President’s Council of Advisors on Science and Technology August 7, 2009 http://www.whitehouse.gov/assets/documents/PCAST_H1N1_Report.pdf (hoping for funding of one time Universal Flu Vaccine) ...$5.8 billion contingent appropriation. After spending an initial $1.85 billion on procurement of vaccines, expansion of surveillance activities, and preparation for a possible immunization campaign, on July 16 the President designated an additional $1.825 billion as emergency funds to support additional measures related to influenza vaccination efforts, leaving $3.975 billion in reserve as contingency funds. and .. A major determinant of virus virulence, the expression of a protein called PB1-F2 is absent in the 2009-H1N1 virus , {which was known to cause cell death and was found in viruses responsible for influenza pandemics of 1918-19 (H1N1), 1957 (H2N2), and 1968 (H3N2)) Accounting for the relatively low virulence of the 2009-H1N1 virus. .................................................................................................................... Is the expression of protein PB1-F2 expected to appear this winter? ................................................................................................................... Of interest is the recent finding that the H1N1 virus currently lacks the protein PB1-F2, which is believed to be an important determinant of virulence and lethality in influenza viruses (Osterhaus, A. and Garau, J., 2009). ............ http://science.thomsonreuters.com/pharma/h1n1/ .........................