I've been following the swine flu all year so I haven't been listening to or following up on what H5N1 is doing. Does anyone know what the latest is? Is it still spreading? How many dead so far? Sick? Where? Any info would be great. I was just watching something on TV about viruses and they mentioned avian flu so it got me thinking. Thanks.

 Posted: September 25 2009 at 9:04pm

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 WHO pdf
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..Three H5N1 influenza candidate vaccines are currently under licence application:
 
Denka Seiken and KAKETSUKEN vaccines, submitted for licensing in Japan; 

Microgen Orniflu vaccine, submitted for licensing in the Russian Federation.

Other H5N1 influenza candidate vaccines have not yet been submitted for licensing:

Vaccines in phase III trials: GSK Q-Pan

is close to submission for licensing in the USA;
 
Novartis Aflunov vaccine;

Vaccines in phase II trials: Sanofi-Pasteur vaccine derived from Vietnam/1194 strain

and AFO3-adjuvanted; Solvay vaccine; and Vabiotech vaccine;
 
 
Page 9
Vaccines in phase I trials: Nobilon vaccine.

 
 
Some H5N1 influenza vaccines have been licensed (or submitted) for mock-up/pandemic use only:     ( Emergency)
 
 
 
 
Baxter Celvapan vaccine, authorized for mock-up/pandemic licensing in 2009;

 
The Commonwealth Serum Laboratories (CSL) Panvax vaccine, licensed in Australia in
June 2008;

GSK Daronrix vaccine, licensed in the European Union in March 2007;

Novartis Focetria vaccine, licensed in the European Union in 2007;

Sanofi-Pasteur vaccine derived from Vietnam/1203 strain and non-adjuvanted, licensed in the USAin April 2007; 
 
 
Sanofi-Pasteur Emerflu aluminium adjuvanted vaccine,
recently rejected for licensing in theEuropean Union but accepted for licensing in
Australia (2009).
 
 
The registration status and safety data of licensed and soon-to-be
licensed H5N1 influenza vaccines are summarized in Table 1.

2.1.2 Results of clinical trials
 
 
Egg-derived inactivated vaccines
The following vaccines were developed as
monovalent inactivated vaccine based on the National Institute of Biological Standards and Control (NIBSC) seed virus A/Vietnam/1194/2004/NIBRG-14(clade 1) and grown in eggs:

Biken, Kitasato, Denka Seiken and KAKETSUKEN developed whole-virion vaccines containing15µg of HA antigen adjuvanted with Al(OH)3.

A two-dose regimen 28 days apart using Biken Bk-Pifavaccine induced seroresponses (microneutralization (MN))≥1/40) in 85% of adults.
Vaccine appeared to be safe with no vaccine-related SAE.
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www.who.int
 
 

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