Tracking the next pandemic: Avian Flu Talk |
Where to buy probenecid? |
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northern_mamma
V.I.P. Member Joined: February 16 2006 Status: Offline Points: 53 |
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Posted: February 26 2006 at 1:42pm |
Now that Canadian pharmacies are no longer shipping to the US, I'm having a hard time finding a source for Probenecid. This interview with Dr. Sanjay Gupta provides some info about its use: http://transcripts.cnn.com/TRANSCRIPTS/0511/05/hcsg.01.html "...A doctor in Oregon this week suggested that using a drug called probenecid, along with the antiviral drug Tamiflu may stretch the nation's supply of the drug. Probenecid would allow Tamiflu to stay in the body twice as long. And as a result, could cut the dose needed to combat a possible avian flu infection by half. |
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Rocky
V.I.P. Member Joined: January 07 2006 Location: United States Status: Offline Points: 219 |
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I am also looking for a place to buy Probenecid. Any thoughts? Rocky
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Rocky |
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Spoil sport
Valued Member Joined: March 15 2006 Status: Offline Points: 5 |
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Don't those things work by reducing urine output? Won't more waste products in the blood make the flu infection more severe? |
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fritz
Adviser Group Joined: February 04 2006 Location: United States Status: Offline Points: 332 |
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I really worry about all of you out there who are playing doctor without knowing doses, multiple drug interactions and possible complications at a time when medical assistance may be non-existant!! Good luck. |
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"I am only one; but still I am one, I cannot do everything, but still I can do something. I will not refuse to do the something I can do." -- Hellen Keller
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Frisky
Valued Member Joined: March 14 2006 Location: United States Status: Offline Points: 123 |
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I agree that" playing "doctor can be hazardous to your health. This even applies to physicians practicing outside the scope of their training. On the other hand I strongly remember a day in the ER when I saw 88 patients over 14 hours almost all of whom had influenza. The next day I laid in bed exhausted most of the day. Split into two 8 hour days I would have been OK.The point is that ER surge capacity is limited in every way imaginable and myself and my colleagues will be overwhelmed and expert medical attention may be unavailable. At this time it is more hazardous if you do not learn how to take care of yourself your family and friends. ER Doc |
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It is better to give than to receive.
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Frisky
Valued Member Joined: March 14 2006 Location: United States Status: Offline Points: 123 |
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The best way to learn about drugs such as probenecid is to read the PDR or just do a Google search. Probenecid blocks excretion in the urine of a very long list of drugs .It does not decrease urine output or block excretion of waste products. It is very cheap and easily available. I have been writing probenecid prescriptions with all of my tamiflu prescriptions since at least a month before the article about the er doc in Oregon came out. The problem is that there is no guidance regarding optimal dosing of the combo of drugs. The researchers are working on this problem. My current recommended regimen follows. This is not research proven but is based on the math of excretion of tamiflu and breakdown of probenecid. This is also based on a study published in 2002 by the tamiflu people regarding probenecid. I also am taking into account fairly recent mice studies showing that optimum therapy length is probably 8 days and that optimum dosing needs to be much higher. Take probenecid 500 mg at first onset of possible flu symptoms. In one hour take 150 mg tamiflu. Continue to take probenecid 500mg twice a day for 10 days. On days 2,3,4,6,7,8 take tamiflu 75 mg. On day 5 take tamiflu 150 mg. Before taking any probenecid you need to read all of the drug interactions list . Another possible regimen may require only 4 tamiflu but it is complicated . Edited by Frisky - April 14 2006 at 5:09pm |
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It is better to give than to receive.
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Thank you Frisky. Your information jibes with what I have been able to glean, given my layman's understanding. I couldn't agree with you more about education ourselves as care-givers of last resort and I appreciate your assistance in furthering our journey along the road of knowledge. Thanks again, Debi |
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