Tracking the next pandemic: Avian Flu Talk |
Flu and Norovirus increasing in U.S. |
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Posted: January 07 2009 at 8:01pm |
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thanks Flu Star - at least someone is painting some colors other than white on the U.S. maps
http://www.flustar.com/ Despite, some rather sparse reports - both flu, Norovirus, and H3N2 are picking up steam in spreading across the U.S. We are at least a moderate - above the commonly reported low - Getting physicians to report flu and test for it is a toughie. Many many flus are lumped into pneumonia depriving us of flu case counts. I have been buried in my word processor since most of my friends and workers are ill. Bluebird STILL is throwing up and it has been weeks. Skye is hardly eating and looks pale and despite a weak smile when he sees daddy or mommy or doggie or kitty - he is getting fairly badly dehydrated. We are pushing liquids big time and gatorade. So the news is - Well these sparse reporting days as we approaching the Olympics of politics in the U.S. January 20 - are rather muffled and gagged (no pun intended- despite the projectile emesis of the nasty Noro which is NOT 24-72 hours. Many people, and I get hundreds of letters a day (email) relating offices, (just today a whole ton of them with a lot of people out with "that nasty bug." So, people don't want to talk about the nether regions of their intestines and Skye who was lock and loaded to hurl q hours a few days ago. Its not gone. Jan and Feb are the big months.. and really the reporting on this is pathetic. If you go to 'the sites' for outbreaks you are going to see stuff from 2006 and 2007. This is really sad. This isn't breaking news, this is broken news.. and long dead. Why put this up at all. Its filler for the real stuff we need to be seeing and hearing about, while the national media tip toes around the gut wrenching no fun war, terrible economics, Iran still playing pick up sticks with the plutonium dust, and there are strains running around that have been resistant to our arsenal and stockpile of drugs for three years. Medclinician is not dead.. he is getting ready to drop the book bomb. The one that will release a lot of new data- Looking like its going to be a mild flu season.. two thumbs down on the reality scale. A lot Xs are in Texas - wouldn't it be interesting to see a flu map of Mexico where those little reds go to? Medclinician |
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This is why it spreads so easily and why there are large outbreaks on ships, in schools, hospitals, day care, the workplace.>>>
Caliciviruses are transmitted via the fecal-oral
or the respiratory route.
Norovirus ...previously called "Norwalk-like viruses"
When a person becomes infected with norovirus, the virus begins to multiply within the small intestine. After approximately 1 to 2 days, norovirus symptoms can appear.
The Caliciviridae family include the following genera:
Australia and New Zealand, in an effort to control their rabbit populations, have intentionally spread calicivirus. more on that-
Rabbit Haemorrhagic Disease Virus (RHDV) is widely used in Australia to control feral rabbit populations. Before RHDV was released on the Australian continent in 1996, antibodies cross-reacting in RHDV specific ELISAs were found in Australian wild rabbits, leading to the hypothesis that a non-pathogenic calicivirus had been circulating in rabbit populations in Australia,
potentially providing some level of cross-immunoprotection to RHDV infection. For the detection of this putative virus, a universal lagovirus PCR test was developed to screen a variety of different tissues of wild caught rabbits. We identified a new lagovirus in the intestinal tissues of three apparently healthy young wild rabbits.
Quantitative Real Time PCR analysis revealed high concentrations of viral RNA in intestinal tissues and suggests a faecal-oral mode of transmission. Genome organisation and phylogenetic analysis following the sequencing of the entire viral genome revealed a new member of the genus Lagovirus within the family Caliciviridae.
Calicivirus infections commonly cause acute gastroenteritis,which is the inflammation of the stomach and intestines.
Symptoms can include vomiting and diarrhoea. These symptoms emerge after an incubation time of 2 days and the symptoms only generally last for 3 days.
In China they call it -
"winter vomiting disease"
ingestion of raw or cooked foods without (including: shellfish, salads and raw vegetables) will be more susceptible to Norwalk-like virus infection.
Norwalk virus is the prototype of a family of unclassified small round structured viruses (SRSVs) which may be related to the caliciviruses. They contain a positive strand RNA genome of 7.5 kb and a single structural protein of about 60 kDa. The 27-32 nm viral particles have a buoyant density of 1.39-1.40 g/ml in CsCl. The family consists of several serologically distinct groups of viruses that have been named after the places where the outbreaks occurred. In the U.S., the Norwalk and Montgomery County agents are serologically related but distinct from the Hawaii and Snow Mountain agents. The Taunton, Moorcroft, Barnett, and Amulree agents were identified in the U.K., and the Sapporo and Otofuke agents in Japan. Their serological relationships remain to be determined.
Common names of the illness caused by the Norwalk and Norwalk-like viruses are viral gastroenteritis, acute nonbacterial gastroenteritis, food poisoning, and food infection.
.......................
< id=Uid = value=19044283 name=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultRePanel.Pubmed_RVDocSum.uid sid="3">3:
Todd EC, Greig JD, Bartleson CA, Michaels BS. J Food Prot. 2008 Nov;71(11):2339-73. Review. PMID: 19044283 [PubMed - indexed for MEDLINE] Info from the CDC...
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Great Britain is gripped with this often...
December 02, 2007Norovirus Stressing Britain's HospitalsNorovirus is in the news a lot and not especially noteworthy here at BFJ but the fact that the DailyExpress is reporting a "Black Alert" at some hospitals and a general "stressing" of the system is noteworthy for me.
The piece from the DailyExpress has hints of "political" spinning however, I am well aware of the limitations our modern health care systems have been placed under irrespective of political party in power. It is that "limitation" that drives a great deal of the concerns the "Flu Obsessed" have when thinking about a sever pandemic.
Perhaps it is worth pausing a moment and considering what even a 30% clinical attack rate (CAR) during an influenza pandemic will do to our respective health care systems in light of this Norovirus outbreak.
SZ source...********a_journey_through_the_wor/2007/12/norovirus-stres.html
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Med, ...PUBMED absolutely reeks of this norovirus info... (did you hear the word MILD associated with it?.... must be they never had it. )
Items 1 - 20 of 2506
even this first page will make the jaw drop...
Or these words...
"Calicivirus infections can result in diarrhea, hepatitis, encephalitis, pneumonia, hemorrhage and other symptoms," said Patrick L. Iversen, Ph.D.
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[Selected immunological processes in viral haemorrhagic fevers infections] Niedźwiedzka P, Deptuła W. Przegl Epidemiol. 2008;62(3):523-9. Polish. PMID: 19108514 [PubMed - in process] Identification and partial characterisation of a new lagovirus in Australian wild rabbits. Strive T, Wright JD, Robinson AJ. Virology. 2008 Dec 1. [Epub ahead of print] PMID: 19049842 [PubMed - as supplied by publisher] Todd EC, Greig JD, Bartleson CA, Michaels BS. J Food Prot. 2008 Nov;71(11):2339-73. Review. PMID: 19044283 [PubMed - indexed for MEDLINE] Mladenova Z, Korsun N, Geonova T, Di Bartolo I, Fiore L, Ruggeri FM; Norovirus Study Group. J Med Virol. 2008 Dec;80(12):2161-8. PMID: 19040294 [PubMed - indexed for MEDLINE] Wang JD, Fang J, Han XH. Bing Du Xue Bao. 2008 Sep;24(5):409-13. Review. Chinese. No abstract available. PMID: 19035333 [PubMed - indexed for MEDLINE] Emerging GII.4 norovirus variants affect children with diarrhea in Palermo, Italy in 2006. Ramirez S, Giammanco GM, De Grazia S, Colomba C, Martella V, Arista S. J Med Virol. 2009 Jan;81(1):139-45. PMID: 19031454 [PubMed - indexed for MEDLINE] Preventing norovirus transmission: how should we handle food handlers? Moe CL. Clin Infect Dis. 2009 Jan 1;48(1):38-40. No abstract available. PMID: 19025494 [PubMed - indexed for MEDLINE] Malek M, Barzilay E, Kramer A, Camp B, Jaykus LA, Escudero-Abarca B, Derrick G, White P, Gerba C, Higgins C, Vinje J, Glass R, Lynch M, Widdowson MA. Clin Infect Dis. 2009 Jan 1;48(1):31-7. PMID: 19025489 [PubMed - indexed for MEDLINE] Liu G, Ni Z, Yun T, Yu B, Chen L, Zhao W, Hua J, Chen J. J Gen Virol. 2008 Dec;89(Pt 12):3080-5. PMID: 19008396 [PubMed - in process] La Rosa G, Pourshaban M, Iaconelli M, Muscillo M. Arch Virol. 2008;153(11):2077-83. Epub 2008 Nov 6. PMID: 18985275 [PubMed - indexed for MEDLINE] [Study on recovery of norovirus from bread] Arita T, Kimura H, Noda M, Nishio O. Kansenshogaku Zasshi. 2008 Sep;82(5):473-5. Japanese. No abstract available. PMID: 18975594 [PubMed - indexed for MEDLINE] [Norovirus infection outbreaks in Kyoto City--2006-2007] Kitagawa S, Usui T, Ishikawa Y, Matsui Y. Kansenshogaku Zasshi. 2008 Sep;82(5):434-40. Japanese. PMID: 18975586 [PubMed - indexed for MEDLINE] Hyperlipidemia in rabbit hemorrhagic disease. Chen SY, Shien JH, Ooi HK. Exp Anim. 2008 Oct;57(5):479-83. PMID: 18946185 [PubMed - indexed for MEDLINE] Jansen A, Stark K, Kunkel J, Schreier E, Ignatius R, Liesenfeld O, Werber D, Göbel UB, Zeitz M, Schneider T. BMC Infect Dis. 2008 Oct 22;8:143. PMID: 18940017 [PubMed - indexed for MEDLINE] Noroviral P particle: structure, function and applications in virus-host interaction. Tan M, Fang P, Chachiyo T, Xia M, Huang P, Fang Z, Jiang W, Jiang X. Virology. 2008 Dec 5;382(1):115-23. Epub 2008 Oct 16. PMID: 18926552 [PubMed - indexed for MEDLINE] Models with insignificant parameters. Buzrul S, Buckow R, Lehmacher A. Appl Environ Microbiol. 2008 Oct;74(20):6481; author reply 6481-2. No abstract available. PMID: 18852214 [PubMed - indexed for MEDLINE] Dzelalija B, Medić A, Leto I, Serić J, Jurić M. Acta Med Croatica. 2008 Jul;62(3):305-8. Croatian. PMID: 18843852 [PubMed - indexed for MEDLINE] Almanza H, Cubillos C, Angulo I, Mateos F, Castón JR, van der Poel WH, Vinje J, Bárcena J, Mena I. J Clin Microbiol. 2008 Dec;46(12):3971-9. Epub 2008 Oct 8. PMID: 18842943 [PubMed - indexed for MEDLINE] Le Guyader FS, Le Saux JC, Ambert-Balay K, Krol J, Serais O, Parnaudeau S, Giraudon H, Delmas G, Pommepuy M, Pothier P, Atmar RL. J Clin Microbiol. 2008 Dec;46(12):4011-7. Epub 2008 Oct 8. PMID: 18842942 [PubMed - indexed for MEDLINE] [Assessment of a new ELISA technique for diagnosing outbreaks of gastroenteritis due to norovirus] Sanz JC, Fernández M, Herranz N, Sánchez-Fauquier A. Enferm Infecc Microbiol Clin. 2008 Aug-Sep;26(7):478-9. Spanish. No abstract available. PMID: 18842247 [PubMed - indexed for MEDLINE] |
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Note brought to my attention on flu spreading Britain by Bluebird. That is we have comments dated December 15th. I have no clue why I have hit a media blackout from Dec 15 of trying to track this U.K., Europe, and most of all the U.S.
Put it this way - in the last week testing my link says http://www.cdc.gov/flu/weekly/ ending January 3, 2009 we have a 3.2% infection rate of the samples that tested positive.
This would indicate an increase in the positives. If you extrapolate 3.2 to U.S. population that is 96,000 cases at the current rate. That would mean we only have an average of 1900 cases of flu in each state. It is likely that we have more cases than that in this city right now. One reason is that cases are being shifted to other diagnosis. This flu appears to have elements of Stept throat, IBS, pneumonia, and one must consider the number of uninsured people who cannot afford to go to ER at $1000-$2000 a pop - and are just staying home. Therefore none of these cases, often including large households of small children or completely off the rradar. As in all statistics (having taken a really painful class in college) there should be a massive margin for error due to non-reporting and non-treated sick people. Bottom line is, these figures do not reflect the accurate infection rate of flu in the U.S. <posting> Medclinician |
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