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Tracking the next pandemic: Avian Flu Talk

Can someone explain this story?

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pheasant View Drop Down
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Post Options Post Options   Thanks (0) Thanks(0)   Quote pheasant Quote  Post ReplyReply Direct Link To This Post Topic: Can someone explain this story?
    Posted: October 12 2014 at 5:24am
This story is from the La Times, and is supposed to be in the New England Journal Of Science. It looks legitimate, and if so, would confirm that what we are being told is not the whole truth.

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Ebola study questions fever as surefire signal
Air passengers screened for Ebola
A plane arrives at New York's John F. Kennedy Airport on Saturday, the first day of enhanced screening of travelers arriving from West African countries that have been affected by Ebola. (Spencer Platt / Getty Images)
By David Willman contact the reporter
Medical ResearchAfricaHospitals and ClinicsEbolaU.S. Centers for Disease Control and Prevention
An Ebola study finds that in nearly 13% of “confirmed and probable” cases tracked, there was no fe
Some experts say the assumption that Ebola spreads only when an infected person has fever should be reassessed

For public health workers screening more than 1,000 air travelers who arrive each week in the United States from Ebola-stricken West Africa, one symptom above all others is supposed to signal danger: fever.

So long as an individual's temperature does not exceed 101.5 degrees and there are no visible symptoms of Ebola, health authorities say it should be assumed the person is not infectious.

Yet the largest study of the current outbreak found that in nearly 13% of "confirmed and probable" cases in Liberia, Sierra Leone, Guinea and elsewhere, those infected did not have fevers.

The study, sponsored by the World Health Organization and published online late last month by the New England Journal of Medicine, analyzed data on 3,343 confirmed and 667 probable cases of Ebola.
Airports screening for Ebola

The finding that 87.1% of those infected exhibited fever — but 12.9% did not — illustrates the challenges confronting health authorities as they struggle to contain the epidemic.

U.S. health officials have repeatedly emphasized that fever is a reliable sign of infectiousness. As a defense against the spread of the virus to this country, the Obama administration has ordered that passengers arriving from West Africa at five U.S. airports be checked for fever.

Dr. Thomas Frieden, director of the U.S. Centers for Disease Control and Prevention, underlined the importance of fever in discussing the case of Thomas E. Duncan, a Liberian who traveled by air to Dallas and was diagnosed with Ebola. He died Wednesday.

Referring to those who had close contact with Duncan, Frieden said a week ago: "The only thing we need to ensure is that their temperature is monitored, and if they develop a fever, that they are immediately assessed, isolated and if found to be positive, then appropriately cared for."
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Frieden has said that about 150 air passengers per day — or 1,050 per week — enter the U.S. from Liberia, Sierra Leone and Guinea, the countries at the heart of the outbreak.

Dr. Anthony Fauci, who is helping to shape the U.S. response to Ebola as director of the National Institute of Allergy and Infectious Diseases, was asked by a CNN interviewer on Oct. 4 whether a person could be "contagious without having a fever."

Fauci replied that "the answer to that is no."

He continued: "You never say 100% but it's essentially 100%. … In biology nothing is 100%, but that's quite a reasonable conclusion to make."

Asked in the same interview about screening of air travelers, Fauci said, "Almost invariably, fever is the thing that signals the onset."

Reached for comment for this article, Fauci said by email that studies of Ebola outbreaks "usually underestimate by a few percentage points the actual percent of people" who have fever.
It seems that only measuring the temperature as a form of triage is insufficient. ... It seems that Ebola can present without fever especially in the first phase. - Nick Zwinkels, Dutch physician who closed a Sierra Leone hospital after Ebola killed members of his staff

The official assumptions about the frequency of fever in Ebola patients have not been challenged publicly. But Dr. Paul D. Stolley, former chairman of the University of Maryland's Department of Epidemiology and Preventive Medicine, said the matter "requires further investigation."

Given the stakes, he said, the "absolute" assumption that Ebola can be spread only when an infected person displays fever should be reevaluated.

"It may be true," said Stolley, a member of the Institute of Medicine, part of the National Academies. "It just doesn't sound very plausible to me."

As of Friday, the current outbreak had killed 4,033 people, according to the CDC. There is no proven cure for Ebola.
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The authors of the recent World Health Organization study said they analyzed "a detailed subset of data" on confirmed and probable cases, including information from forms completed by doctors and other healthcare workers in the affected countries, indicating whether a patient had a fever and at what temperature and whether the reading was taken by armpit, by mouth or rectally.

The study defined fever as 38 degrees Celsius — 100.4 degrees Fahrenheit.

"To create the fullest possible picture of the unfolding epidemic," the authors said, they collected additional information from "informal case reports" and other sources.

The researchers described imperfections in some of the data. In a footnote, they wrote that "in practice, healthcare workers at the district level often do not have a medical thermometer and simply ask whether the person's body temperature is more elevated than usual."

Yet the lead author, Dr. Christl Donnelly, a professor of statistical epidemiology at Imperial College London, stood by the findings on the prevalence of fever.

Asked by email whether the study found no fever in 12.9% of confirmed and probable cases, Donnelly replied: "Yes."
Ebola crisis
Caption Ebola crisis
John Moore / Getty Images
A Doctors Without Borders health worker in protective clothing carries a child suspected of having Ebola at a treatment center in Paynesville, Liberia. The girl and her mother, showing symptoms of the deadly disease, were awaiting test results on Oct. 5.
Ebola crisis
Caption Ebola crisis
John Moore / Getty Images
A member of the U.S. Air Force pauses to re-hydrate while setting up a 25-bed hospital to aid Liberian health workers infected with Ebola near Monrovia on Oct. 8.
Ebola crisis
Caption Ebola crisis
Pascal Guyot / AFP/Getty Images
A worker washes up at a construction site in Monrovia. Liberia is the worst hit of the West African nations at the center of the epidemic, which has already killed 3,439 people, of these, 2,069 in Liberia, according to the latest figures from the World Health Organization.
Ebola crisis
Caption Ebola crisis
Jerome Delay / Associated Press
Mercy Kennedy, 9, cries outside her Monrovia home after her mother was taken away to an Ebola ward in Liberia. Neighbors wailed Oct. 2 upon learning that Mercy's mother had died; she was among the cluster of cases that includes Thomas Eric Duncan, who died after being hospitalized in Texas.
Ebola crisis
Caption Ebola crisis
John Moore / Getty Images
Grave diggers prepare for new Ebola victims outside a treatment center near Gbarnga, in Bong County in central Liberia.

Three studies of previous outbreaks, cited in the same World Health Organization report, provide further grounds to question whether fever is a fail-safe signal.

Researchers studying an outbreak in Uganda in late 2000 and early 2001 reported that "the commonest symptom … was fever, which occurred in 85% of the cases."

Another study of that outbreak, focusing on 24 confirmed cases of Ebola, found fever in 88%.

The third study, which examined a 1995 outbreak in the Democratic Republic of Congo, found fever in 93% of 84 people who died and in 18 of 19 individuals who survived.

Asked Friday how many people infected in the current outbreak should be expected to display fever, a CDC spokeswoman, ******** Hoskins, said "the vast majority" would, but added that it was "impossible to give an exact percentage."

For doctors and nurses fighting the epidemic in West Africa, the risk of encountering Ebola in the absence of fever is more than academic.

Dr. Nick Zwinkels, a Dutch physician, last month closed a hospital he had been running with a colleague in central Sierra Leone after five nursing aides contracted Ebola — possibly from unprotected contact with three patients who were not promptly diagnosed with the virus.

Four of the nursing aides died, as did all three of the patients belatedly found to have Ebola.

Interviewed by email, Zwinkels said that hospital staff members took the temperature of one of the doomed patients four times a day for three consecutive days, and the patient never showed a fever. The readings were taken by a digital thermometer placed in the armpit, he said.

Based on what his staff observed, Zwinkels wrote, "it seems that only measuring the temperature as a form of triage is insufficient."

He added: "It seems that Ebola can present without fever especially in the first phase."

Zwinkels said that without fever as a trustworthy marker, it is difficult for medical professionals to treat the many West Africans suffering from everyday maladies.

The clinic that Zwinkels operated for the Rotterdam-based Lion Heart Foundation was established to treat malaria patients but cared for a handful found to have Ebola, while trying to arrange their transfer to a more qualified facility.

If Ebola cannot be readily identified, Zwinkels wrote, "Ebola patients will be admitted in the normal ward and possibly contaminating health staff and caretakers. This is why a lot of hospitals in West Africa are closed. … Millions of people don't have any healthcare at the moment because hospitals treat Ebola only or are closed."
Timeline
Key events in the spread of Ebola
Key events in the spread of Ebola
Alexandra Zavis, Monte Morin

Zwinkels said he looked forward to returning to Sierra Leone and felt torn between raising awareness about the cases he saw and sowing panic.

"This outbreak is completely out of control, and the only way to stop [it] is to find every case, isolate them and trace their contacts," he wrote.

http://www.latimes.com/nation/la-na-1012-ebola-fever-20141012-story.html#page=1
The only thing we have to fear, is fear itself......FDR
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Post Options Post Options   Thanks (0) Thanks(0)   Quote Albert Quote  Post ReplyReply Direct Link To This Post Posted: October 12 2014 at 6:57am
The Frienden/Fauci wonder twins have been downplaying and putting their own spin on things for awhile now.  Trust about 90% of what they say.  The other 10% that they sway the truth on is scary.

Another quick example of the spin machine - Every time people/media say we should stop "outgoing flights" from Liberia, they immediately respond with we must let "flights in" there, lol.   Two different things and they spin the subject.  Then when reporters ask, what about letting flights in, but banning outgoing flights?  They respond the same, we have to allow flights in and can't isolate them.   Comical.

It's pretty clear that folks can probably shed the virus a day or two prior to fever and symptoms.  Without visible symptoms and bodily fluids spewing every, it might be more difficult to catch a couple days prior to symptoms, but I'm sure it happens i.e. kissing, sexual contact, sharing utensils, a rogue cough/sneeze, etc...  Wait until we see coinfections with flu and Ebola and shedding the virus early.

They should retest high risk cases throughout the entire incubation process around every 3 days to find out.  or start testing them after day 10.   Something tells me the wonder twins frieden and fauci know this. If most become symptomatic around day 10, i wonder if the non symptomatic cases after day 10 are becoming a little infectious, although again it's harder to come in contact with their bodily fluids.

Tells you what we're going to have to deal with during a severe pandemic regarding information.

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Post Options Post Options   Thanks (0) Thanks(0)   Quote onefluover Quote  Post ReplyReply Direct Link To This Post Posted: October 12 2014 at 7:44am
Funny. The 10 or 12% infected with no fever are similar in number to the 10% truthfulness. Not funny is those percentages are what can rock our world. I think the 12%ers are to be expected in that there may be other factors masking ones fever. Some people may have a condition that tends to give them an unusually low temp. Below 98.6f. Then the beginnings of Ebola brings it back up to, say 99.5. Well below radar. I am only mildly overweight. My blood pressure is often at 190 over 120. My dad is double his clinical weight. 150 over. Severely obese. His blood pressure routinely reads 110 over 68. It should read much higher. It told me something else is wrong that keeps it unusually down. Then I learn he has severe colitis. Colitis causes low blood pressure. We have also read that Ebola fevers go up and down. These 12% may have been caught on the down cycle (-or missed rather). One thing is for certain as far as I am concerned no matter what is said. Asymptomatics are still infectious to some degree in some means. Only a fool would argue that dangerous oposing point in my opinion.
"And then there were none."
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Post Options Post Options   Thanks (0) Thanks(0)   Quote Germ Nerdier Quote  Post ReplyReply Direct Link To This Post Posted: October 12 2014 at 8:12am
If a sick person is trying to get on a plane, all he has to do is pop a Tylenol.
I'm not suggesting anyone would be less than truthful... ;)
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Post Options Post Options   Thanks (0) Thanks(0)   Quote onefluover Quote  Post ReplyReply Direct Link To This Post Posted: October 12 2014 at 9:13am
And there is that. GM GN
"And then there were none."
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