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Making Your Supply of Tamiflu Go Further

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    Posted: April 21 2006 at 12:13am
http://www.avoidbirdflu.com/article.php?id1=5224
 
Bird Flu and Tamiflu  Making Your Supply of Tamiflu Go Further in an Emergency Situation
I have discussed Tamiflu (oseltamivir) and Relenza (zanamivir) previously – see Bird Flu: Tamiflu and Relenza for Prevention and Treatment in the Articles section on our Web site, http://www.AvoidBirdFlu.com. This current article adds important information about making your supply of Tamiflu go further in an emergency situation.

First, as I noted in my previous article, it is important to be aware of the fact that the effectiveness of Tamiflu and Relenza has been studied against circulating strains of human influenza (so called seasonal influenza), not against the bird flu virus. In a study reported in the August 2005 issue of the Journal of Infectious Diseases, Dr. Yen and others from St. Jude Children’s Research Hospital in Memphis, Tennessee found that in animal experiments eight-day regimens of Tamiflu were more effective than the suggested five-day regimen for treating infections with the H5N1 bird-flu virus.

The authors concluded that a prolonged and higher-dose oseltamivir regimen may be required for the most beneficial
antiviral effect. This possibility was recently underscored when two Vietnamese (one a 13 year old girl) died of bird flu—as reported in a December 2005 issue of the New England Journal of Medicine—even after receiving treatment within the required 48 hours after the start of infection with standard doses of Tamiflu.

Let’s assume that you have one treatment course of Tamiflu (one 75 mg tablet taken twice a day for five days, for a total of 10 pills), that you either acquired on your own or that was given to you by your healthcare provider or by the government. Unfortunately you are still not home free yet, so to speak. You now may face one of two problems:

Problem # 1: If preliminary scientific studies indicating that a course of treatment of bird flu using higher doses than those currently recommended by the FDA, for more than the current recommended five days of treatment are correct—as indicated by Dr. Yen’s research—you will need more that one dose pack. In fact, the best treatment might mean taking two pills (150 mg) twice a day for eight or even ten days. That would mean that you should have FOUR dose packs (40 pills) for the treatment of one person, not just one!

Problem # 2: You have a dose pack—officially the amount need to treatment one person—but there are two people who just became infected with bird flu in your family. If you combine this problem with problem number one, you now actually need EIGHT dose packs, not just two!

What can you do? There are two possible solutions:

SOLUTION # 1: Take PROBENECID, a medicine approved for the treatment of gout, along with the Tamiflu. Probenecid interferes with the normal
metabolism of Tamiflu, increasing the blood level of Tamiflu and keeping it in circulation longer—effectively doubling the amount of Tamiflu “exposure.” The precise dose is unclear. Until more scientific information becomes available, in an emergency situation, for otherwise healthy adults, I would recommend taking one 500 mg table twice daily. Probenecid is generally very safe. Nevertheless, I have included detailed information about it below.

According to information about probenecid from the National Library of Medicine’s and the National Institutes of Health’s Web site Medline Plus (available at
http://www.nlm.nih.gov/medlineplus/druginfo/uspdi/202480.html):

Probenecid (proe-BEN-e-sid) is used in the treatment of chronic gout or gouty
arthritis. These conditions are caused by too much uric acid in the blood. The medicine works by removing the extra uric acid from the body. Probenecid does not cure gout, but after you have been taking it for a few months it will help prevent gout attacks. This medicine will help prevent gout attacks only as long as you continue to take it.

Probenecid is also used to prevent or treat other medical problems that may occur if too much uric acid is present in the body.

Probenecid is sometimes used with certain kinds of antibiotics to make them more effective in the treatment of infections.

Probenecid is available only with your doctor's prescription, in the following dosage form (tablets):

a. Before Using This Medicine

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For probenecid, the following should be considered:

Allergies—Tell your doctor if you have ever had any unusual or
allergic reaction to probenecid. Also tell your health care professional if you are allergic to any other substances, such as foods, preservatives, or dyes.

Pregnancy—Probenecid has not been shown to cause birth defects or other problems in humans.

Breast-feeding—Probenecid has not been reported to cause problems in nursing babies.

Children—Probenecid has been tested in children 2 to 14 years of
AGE for use together with antibiotics. It has not been shown to cause different side effects or problems than it does in adults. Studies on the effects of probenecid in patients with gout have been done only in adults. Gout is very rare in children.

Older adults—Many medicines have not been studied specifically in older people. Therefore, it may not be known whether they work exactly the same way they do in younger adults. There is no specific information comparing use of probenecid in the elderly with use in other
AGE groups.

Other medicines—Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking probenecid, it is especially important that your health care professional know if you are taking any of the following:

• Antineoplastics (
cancer medicine)—The chance of serious side effects may be increased

• Aspirin or other salicylates—These medicines may keep probenecid from working properly for treating gout, depending on the amount of
aspirin or other salicylate that you take and how often you take it

• Heparin—Probenecid may increase the effects of heparin, which increases the chance of side effects

• Indomethacin (e.g., Indocin)

• Ketoprofen (e.g., Orudis)

• Methotrexate (e.g., Mexate)—Probenecid may increase the
blood levels of these medicines, which increases the chance of side effects

• Medicine for infection, including tuberculosis or virus infection—Probenecid may increase the
blood levels of many of these medicines. In some cases, this is a desired effect and probenecid may be used to help the other medicine work better. However, the chance of side effects is sometimes also increased

• Nitrofurantoin (e.g., Furadantin)—Probenecid may keep nitrofurantoin from working properly

• Zidovudine (e.g., AZT, Retrovir)—Probenecid increases the
blood level of zidovudine and may allow lower doses of zidovudine to be used. However, the chance of side effects is also increased

Other medical problems—The presence of other medical problems may affect the use of probenecid. Make sure you tell your doctor if you have any other medical problems, especially:

• Blood disease or

• Cancer being treated by antineoplastics (
cancer medicine) or radiation (x-rays) or

• Kidney disease or stones (or history of) or

• Stomach ulcer (history of)—The chance of side effects may be increased

b. Proper Use of This Medicine If probenecid upsets your stomach, it may be taken with food. If this does not work, an antacid may be taken. If stomach upset (nausea, vomiting, or loss of appetite) continues, check with your doctor.

For patients taking probenecid for gout:

• After you begin to take probenecid, gout attacks may continue to occur for a while. However, if you take this medicine regularly as directed by your doctor, the attacks will gradually become less frequent and less painful than before. After you have been taking probenecid for several months, they may stop completely.

• This medicine will help prevent gout attacks but it will not relieve an attack that has already started. Even if you take another medicine for gout attacks, continue to take this medicine also. If you have any questions about this, check with your doctor.

For patients taking probenecid for gout or to help remove uric acid from the body:

• When you first begin taking probenecid, the amount of uric acid in the kidneys is greatly increased. This may cause kidney stones or other kidney problems in some people. To help prevent this, your doctor may want you to drink at least 10 to 12 full glasses (8 ounces each) of fluids each day, or to take another medicine to make your urine less acid. It is important that you follow your doctor's instructions very carefully.

Dosing—

The dose of probenecid will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of probenecid. If your dose is different, do not change it unless your doctor tells you to do so.

• For treating gout or removing uric acid from the body:

? Adults: 250 mg (one-half of a 500-mg tablet) two times a day for about one week, then 500 mg (one tablet) two times a day for a few weeks. After this, the dose will depend on the amount of uric acid in your
blood or urine. Most people need 2, 3, or 4 tablets a day, but some people may need higher doses.

Children: It is not likely that probenecid will be needed to treat gout or to remove uric acid from the body in children. If a child needs this medicine, however, the dose would have to be determined by the doctor.

• For helping antibiotics work better:

Adults: The amount of probenecid will depend on the condition being treated. Sometimes, only one dose of 2 tablets is needed. Other times, the dose will be 1 tablet four times a day.

Children: The dose will have to be determined by the doctor. It depends on the child's weight, as well as on the condition being treated. Older children and teenagers may need the same amount as adults.

Missed dose—

If you are taking probenecid regularly and you miss a dose, take the missed dose as soon as possible. However, if you do not remember until it is almost time for the next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

Storage—

To store this medicine:

• Keep out of the reach of children.

• Store away from heat and direct light.

• Do not store this medicine in the bathroom, near the kitchen sink, or in other damp places. Heat or moisture may cause the medicine to break down.

• Do not keep outdated medicine or medicine no longer needed. Be sure that any discarded medicine is out of the reach of children.

c. Precautions While Using This Medicine

• If you will be taking probenecid for more than a few weeks, your doctor should check your progress at regular visits.

Before you have any medical tests, tell the person in charge that you are taking this medicine. The results of some tests may be affected by probenecid.

For diabetic patients:

• Probenecid may cause false test results with
copper sulfate urine sugar tests (Clinitest®), but not with glucose enzymatic urine sugar tests (Clinistix®). If you have any questions about this, check with your health care professional.

For patients taking probenecid for gout or to help remove uric acid from the body:

• Taking
aspirin or other salicylates may lessen the effects of probenecid. This will depend on the dose of aspirin or other salicylate that you take, and on how often you take it. Also, drinking too much alcohol may increase the amount of uric acid in the blood and lessen the effects of this medicine. Therefore, do not take aspirin or other salicylates or drink alcoholic beverages while taking this medicine, unless you have first checked with your doctor.

d. Side Effects of This Medicine

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

The following side effects may mean that you are having an
allergic reaction to this medicine. Check with your doctor immediately if any of the following side effects occur:

• Rare

Fast or irregular breathing; puffiness or swellings of the eyelids or around the eyes; shortness of breath, troubled breathing, tightness in chest, or wheezing; changes in the skin color of the face occurring together with any of the other side effects listed here; or skin rash, hives, or itching occurring together with any of the other side effects listed here

Also, check with your doctor as soon as possible if any of the following side effects occur:

• Less common

Bloody urine; difficult or painful urination ; lower back or side pain (especially if severe or sharp); skin rash, hives, or itching (occurring without other signs of an
allergic reaction)

• Rare

Cloudy urine; cough or hoarseness; fast or irregular breathing; fever; pain in back and/or ribs; sores, ulcers, or white spots on lips or in mouth; sore throat and fever with or without chills; sudden decrease in the amount of urine; swelling of face, fingers, feet, and/or lower legs; swollen and/or painful glands ; unusual bleeding or bruising; unusual tiredness or weakness; yellow eyes or skin ; weight gain

Other side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. However, check with your doctor if any of the following side effects continue or are bothersome:

• More common

Headache; joint pain, redness, or swelling ; loss of appetite; nausea or vomiting (mild)

• Less common

Dizziness; flushing or redness of face (occurring without any signs of an
allergic reaction); frequent urge to urinate; sore gums

Other side effects not listed above may also occur in some patients. If you notice any other effects, check with your doctor.

SOLUTION # 2: Unless you are a divine follower of the late Mahatma Gandhi, who used to drink his urine daily, this solution is not nearly as appealing as taking probenecid. However, it apparently would be very effective. Dr. Grattan Woodson, a specialist in internal medicine at the Druid Oaks Health Center in Decatur, Georgia, offers the following advice for emergency treatment of bird flu:* This is an advanced, potentially life-saving emergency strategy, that should only be done under medical supervision—unless none is available.

Tamiflu Re-Administration Strategy: Tamiflu is excreted unchanged almost entirely in the urine. If Tamiflu supplies are limited, as they most certainly will be [during a bird-flu pandemic], consider giving the patient two Tamiflu tablets at the same time, collect the patient’s urine and re-administer it to the patient via naso-gastric (NG) tube or orally. If managed carefully, this approach means that you can completely treat a patient with only 2 Tamiflu tablets [by re-administering the patient’s urine daily for five to 10 days].


*Woodson G: Preparing for The Coming Influenza Pandemic. *********. Available at:
http://*********/annex/WoodsonMonograph.htm#_Toc116746508.

Bradford Frank, M.D., M.P.H., M.B.A.
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Is there anyway of getting Tamiflu, without having to go through your doctor.
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Until now there is no medicament can stop the avian bird flu .
 
i have find that real way to escape , is Yakuso anti flu (personal air purifier)
 
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yakuso generates anion via negative corona discharge. When negative
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What is important is how to control the concentration of anion. yakuso air cleaner emits 186 billion electrons per second to purify contaminated air, and keeps anion density at 1000 ea per 1cc of air or more to do good to human body.

Activated Carbon in Yakuso Air Purifiers :

I. Introduction
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II. History and Use in Purification Processes
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Yakuso netative ions
Negative ions help freshen and purify the air by causing allergens such as pollen, mold spores, dust, and animal dander floating in the air (which have either a neutral or a positive charge) to be attracted to and stick to each other, forming 'clumps' (because opposite charges attract). These clumps of particles then become heavy enough so that gravity can pull them down to the floor, where they can be vacuumed up, rather than staying in suspension where they can be breathed in and cause allergic reactions.
The following diagram will explain how negative ions remove the pollutants from the air.
Negatively-charged negative ions attach themselves to contaminates and allergens, which are positively-charged. The newly-formed larger particles are then able to fall to the ground, and out of the air we breathe.

Function of Ultraviolet (UV) germicidal light :
UV — found in sunlight — is at the range of 254 Nm and its photons have just the right level of energy to physically destroy the DNA of microorganisms.
Ultraviolet germicidal protection is a safe and proven technology that uses lamps resembling ordinary fluorescent tubes to generate UVC light to kill bacteria, mold, spores and viruses. Unlike antibiotics, microorganisms cannot develop immunity to UVC light. Viruses are especially susceptible to destruction by UVC.

Yakuso Titanium dioxide :
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Yakuso Ozone
Ozone : Our ozone generator will generate the high voltage to produce the ozone. The following diagram will explain the odor removal principle.

1) Purification of air:
Various contaminated substances in the air such as cigarette smoke, sulfurous acid gas(SO2),nitrous oxide gas(NOx) and carbon monoxide gas(CO) create positive ions. However, anions generated by air cleaner neutralize, settle and remove these positive ions to keep air clean and fresh. The harmful substance such as ozone reduces to negatively charged oxygen(O2-) via following reaction, and plays an important role in settling problems with deficiency of oxygen.

2) Removal of dust and bacteria:
Positive ions enable bacteria, dust, pollen, mold and contaminated particulates freely float and make foul air. However, anions electrically neutralize and remove them, or charged them negatively so that they are adsorbed and collected by a positively charged powerful dust collector plate installed in the air cleaner.

3) Humidity control:
yakuso air cleaner controls humidity more or less. For example,
It reduces harmful ozone to negatively charged oxygen through the following reaction.
O3 + 2H + 2E -> O2 + H2O
This equation shows that water(H2O) is generated and helps control humidity.

4) Deodorization:
Anion chemically oxidizes, decomposes and neutralizes the source of odor to remove
offensive odor and keep indoor atmosphere pleasant.

Yakuso - The best for pollen allergies
Pollen is a tricky type of allergen and can cause many ruined days for people who suffer from allergies. Pollen can easily become airborne and can be tracked to the indoors from the outdoors by people, animals or a simple gust of wind. It re-circulates in the air indoors and is a threat to any resident with sensitivities to the particle. It’s hard to believe that a small, microscopic particle in the air can give a person so many horrific symptoms but pollen is, unfortunately, a powerful allergen.But with Yakuso you will forget it for life.

Yakuso - The best for dust
One of the most common household contaminants that are present in most residences is dust. Dust can be a hard contaminant to get rid of and dusting or cleaning does not always do the trick. Even the cleanest of homes can still contain dust even if it’s not seen on any objects or furniture. Dust mostly contains flakes of skin and dirt. It can also contain pet hair, pet dander and dust mites. These types of particles can become very harmful for residents when they are breathed in. Residents with sensitivities, allergies or asthma can experience symptoms to their conditions when exposed to dust in the air. By breathing in house dust, residents may be breathing in contaminants such as dust mites or pet dander, which can be harmful to air passageways. In order to remove dust from their homes, many people try different dusting chemicals and different types of materials to make the dust cling so it can be eliminated from the environment. However, it is very seldom that these cleaning products or materials actually work and are able to grasp the dust and remove it from objects. Therefore, the dust becomes airborne in the room and can easily be breathed in by any residents that are present. Many dusting materials simply stir the dust up and make it more easily accessible to air passageways . Yakuso are the best way to actually remove the dust from indoor air.

Yakuso-The best for Pet Dander
According to the American Lung Association and Clearflite, reducing the amount of exposure a person with allergies has to a pet is the best ways to prevent allergic reactions. However, many pet owners consider their pets to be members of the family, almost like adopted children. Issues such as the presence of clean indoor air just aren’t big enough problems for a pet owner to even think about getting rid of a pet. Unfortunately for many pet owners, the quality of their home indoor air does suffer when a pet is brought into the home. Pets not only shed hair that can cause allergic reactions but can also cause pet dander to become present in the indoor air. Luckily,pet owners can use Yakuso to solve the problem .

Yakuso- The best for MCS
It is still debatable as to whether Multiple Chemical Sensitivity is considered a true medical condition or a simple sensitivity. However, for the people who suffer from this condition, it can be one of the most frustrating and intrusive ways to live. Multiple Chemical Sensitivity, or MCS, is when a person is extremely sensitive to many different types of everyday chemicals. These chemicals can include paint fumes, hairstyling spray, perfumes and air fresheners. Since most of these chemicals cannot be avoided and have to be faced on a daily basis, people suffering from the condition often feel the symptoms everyday. Symptoms of MCS include itchy and watery eyes, dizziness, sore throat or even nausea. For MCS sufferers, removing any chemical fumes from a home indoor air is the best and healthiest way for them to live. With aYakuso, a MCS sufferer can have a safe haven from his or her condition.


Yakuso - The best for Bacteria and Virus Problems
Colds, flu , Sars, and other viruses are usually spread through microorganisms that become airborne. The microorganisms are then transmitted from one person to another by breathing in the air indoors that contains the contaminant. The spread of bacteria and viruses that are airborne can easily happen inside a home due to the confinement of air. Since homes are sealed completely tight for climate and safety purposes, the air that is contained inside a home cannot escape from the residence. If this home is contaminated with microscopic bacteria and microorganisms, they will simply re-circulate throughout the home because they have nowhere else to go. With the microorganisms re-circulating through the indoor air, it is apparent that the residents inside the home will breathe in the contaminated air. By breathing in air that contains these microorganisms or bacteria, residents are at a high risk of catching a cold or flu. Although all people are at risk for catching a cold or flu, young children, elderly people or residents with a weaker immune system are more at risk to contract an illness from airborne microorganisms. In order to eliminate these microorganisms and stop them from re-circulating a home air,Yakuso can be run inside the home to remove these particles or every were.
 
 
 

 
 
 
 
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