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Now tracking the new emerging South Africa Omicron Variant

On vaccines...

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Dutch Josh View Drop Down
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Post Options Post Options   Thanks (0) Thanks(0)   Quote Dutch Josh Quote  Post ReplyReply Direct Link To This Post Topic: On vaccines...
    Posted: July 20 2022 at 10:10pm

DJ, 

There is -and should be- a lot of discussion on vaccines. 

In this CoViD pandemic vaccines may play a role, Discussion on what role, how, who pays what could/should maybe bring better stategies...

I know not much of vaccines...just some basic info...Contact with weak or dead virus particles could start an immune response in a host...Those virus particles can be replaced by messanger RNA (m-RNA) to create a likewise reaction...as a basic idea as far as I understand it....

-Strategies;

Of course history is full of diseases and pandemics....people did all kind of things "to try and limit risks"...

Scapegoats, blaming some groups in the population, another country, is still very popular today but not very effective (and not science...).

So in most of history there was a sort of selection;

blame games started often by leaders that wanted to stay in position...

non-pharma interventions by other "leaders"...

-Non Pharma Interventions;

Most of history people did not live with a pharma-industry producing vaccines, medication...limiting (close) contacts, all kind of protection-masks, incense, ginger etc had to offer protection...I think some of those steps became the basis of early medical, pharma science...thousends of years ago...

Some diseases were caused by poison food, water...other diseases by infection...So a cure may work in some cases, not in others...

Till this day Non pharma Interventions keep making sense; low budget, easy to do....problem is more how long to do it...

[url]https://en.wikipedia.org/wiki/Quarantine[/url] or https://en.wikipedia.org/wiki/Quarantine ;

The word quarantine comes from quarantena or quarantaine, meaning "forty days", used in the Venetian language in the 14th and 15th centuries and also in France. The word is designated in the period during which all ships were required to be isolated before passengers and crew could go ashore during the Black Death plague. The quarantena followed the trentino, or "thirty-day isolation" period, first imposed in 1347 in the Republic of RagusaDalmatia (modern Dubrovnik in Croatia).[1][2][3][4]

Merriam-Webster gives various meanings to the noun form, including "a period of 40 days", several relating to ships, "a state of enforced isolation", and as "a restriction on the movement of people and goods which is intended to prevent the spread of disease or pests". The word is also used as a verb.[5]

Quarantine is distinct from medical isolation, in which those confirmed to be infected with a communicable disease are isolated from the healthy population.[6]

Quarantine may be used interchangeably with cordon sanitaire, and although the terms are related, cordon sanitaire refers to the restriction of movement of people into or out of a defined geographic area, such as a community, in order to prevent an infection from spreading.[7]

An early mention of isolation occurs in the Biblical book of Leviticus, written in the 7th century BC or perhaps earlier, which describes the procedure for separating out people infected with the skin disease Tzaraath. The medical nature of this isolation is, however, disputed. As traditional exegesis (dated 700 CE) sees it as a punishment for trespassing one of several negative commandment, most notably Evil Speech.[8] A more recent hypothesis postulates that the infected are required to isolate themselves in order to prevent spread of disease[citation needed] (although the Bible does not imply contagiousness of Tzaraath):

Anyone with such a defiling disease must wear torn clothes, let their hair be unkempt, cover the lower part of their face and cry out, "Unclean! Unclean!" As long as they have the disease they remain unclean. They must live alone; they must live outside the camp

DJ, In my view Non pharma Intervention is very effective still...In todays world with internet I think NPI should do the main job...

It would need active governments, medical world defining ways of producing and logistics at the lowest possible pandemic risk. Asian countries may go for this strategy...

End of part 1

We cannot solve our problems with the same thinking we used when we created them.
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Dutch Josh View Drop Down
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Post Options Post Options   Thanks (0) Thanks(0)   Quote Dutch Josh Quote  Post ReplyReply Direct Link To This Post Posted: July 20 2022 at 10:43pm

[url]https://virologyj.biomedcentral.com/articles/10.1186/s12985-022-01831-0[/url] or https://virologyj.biomedcentral.com/articles/10.1186/s12985-022-01831-0 part 2...vaccines;

Adverse effects of COVID-19 vaccines and measures to prevent them

Recently, The Lancet published a study on the effectiveness of COVID-19 vaccines and the waning of immunity with time. 

The study showed that immune function among vaccinated individuals 8 months after the administration of two doses of COVID-19 vaccine was lower than that among the unvaccinated individuals. 

According to European Medicines Agency recommendations, frequent COVID-19 booster shots could adversely affect the immune response and may not be feasible. 

The decrease in immunity can be caused by several factors such as N1-methylpseudouridine, the spike protein, lipid nanoparticles, antibody-dependent enhancement, and the original antigenic stimulus. 

These clinical alterations may explain the association reported between COVID-19 vaccination and shingles. 

As a safety measure, further booster vaccinations should be discontinued. 

In addition, the date of vaccination should be recorded in the medical record of patients. 

Several practical measures to prevent a decrease in immunity have been reported. 

These include limiting the use of non-steroidal anti-inflammatory drugs, including acetaminophen to maintain deep body temperature, appropriate use of antibiotics, smoking cessation, stress control, and limiting the use of lipid emulsions, including propofol, which may cause perioperative immunosuppression. 

In conclusion, COVID-19 vaccination is a major risk factor for infections in critically ill patients.

DJ; Vaccines are NOT the "holy grail" ..do have (lots of) risks...

In my view Non pharma Intervention should be the main-if not only-tool....

There are countries (Haïti, North Korea a.o.) claiming Non Pharma is effective...not because they did not want to go for vaccines, simply because most of the world did not get any vaccines....

-How vaccines are used;

Big Pharma main goal is profit in most (western) countries....Even when a lot of work is funded by tax payers profit is #1....

Big Pharma has a very bad reputation on creating public health risks out of greed, testing on the poor in "countries we keep poor"...

(High risk studies on "gain of functions" of virusses were transferred to countries with less strict rules. The Wuhan-lab some claim "leaked CoViD" did a study on corona virusses paid for by the US but outsourced to China for risk reasons...then starting some a "blame game"..."CCP-virus"...). 

The main goal in many (western) countries of medication, vaccines etc is profit...

-Medical use;

"Non Sterilizing" vaccines limit disease after infection...Sterilizing vaccines stop also the spread of disease...

One of the main problems in CoViD is vaccinated people still getting infected. So you need a wider strategy also including Non Pharma Intervention....STOP THE SPREAD !!!!

Because by now CoViD did see a selection process of mutations that did get better in evading immunity (both after earlier infection and vaccination). Over time vaccines are getting less and less effective in doing their job; limit disease....(they did not stop the infection from the start). 

Strategies on "vaccination only" with non-sterilizing vaccines during a pandemic are the best way to worsen a pandemic....

Vaccines at the start did offer good protection...but NOT stopping the spread made vaccines a danger not a help, a way out....Vaccination strategy was and is the main problem in my non-expert view...

New (nasal) vaccines may offer help-a way out-ONLY !!! in combination with Non Pharma rules (masks, limits of contacts). 

DJ, The discussion on vaccines, pandemics, many other issues, did get "out of control"...In the US "everything became political" and that is not helping...

Social science is needed to get effective communication started...Vaccines, medical world, has to serve public health not shareholders...other then we all being "shareholders" in a way public health is in the interests of us all...

End of part 2 (of me trying to formulate my critical view on vaccines...Yes I did get 2x Pfizers, 2x Moderna...I do think vaccines have a good use...But I do disagree on making profits out of public healthcare...I think it is a governments job to have good public services and in return for offering those public services (not only healthcare but also housing, FREE !!! education, maybe even FREE-tax funded public transport...) ask for tax from that public...

"Taxation without representation" is the outcome of neo-liberalism in wich governments offer hardly any public services (themselves) and tax money ends up at the 1%...further increasing socio-economic imbalance...This pandemic is political....

We cannot solve our problems with the same thinking we used when we created them.
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Post Options Post Options   Thanks (0) Thanks(0)   Quote KiwiMum Quote  Post ReplyReply Direct Link To This Post Posted: July 21 2022 at 12:04am

The real problem, in my opinion, is that the vast majority are completely over Covid. Most of us have had it and most of us recovered just fine. People just want to get on with their lives and put it behind them. 

Speaking for myself only I'll say that I don't want to wear a mask or have spaced seating. I've had Covid and my first reaction to a positive test was a split second of fear. The governments have done a good job in spreading the fear, but then I got a grip of myself and whilst I had it I logged my symptoms and those of my family and my conclusion was  that yes we were ill, too ill to go to work and too ill to do anything much at all, but only for about 4 or 5 days, then we started to feel better. My children were quicker, and only ill for 3 days. I'm pretty sure we've just had the BA4 or 5 variant and it was like a nasty flu but quite short lived. 

I now consider us to be immune. I know that some people are catching it a second time but the only people I know who are doing that are fully vaccinated. We're strong and healthy. Been there, done that. And everyone my age feels the same. I know some older people who are frightened of it, but I have friends who are actively trying to catch it right now. 

So talk of non pharmaceutical interventions (NPI) is just irritating. It's a vote loser. Covid is rampant here but we're getting closer to the election and the government is losing popularity because it's interfering in our lives too much and affecting our businesses and right now, if it went to the vote, Labour would be out. I'm a grown up and I don't need mothering by Jacinda or anyone else. The governments of the world are turning their countries into nanny states and no one wants that. 

Personally I think they should abolish all restrictions and just let the individual take whatever precautions they feel are right for them. 

Covid is just like the flu, in fact, to me who has had both flu and Covid, I'd say they are indistinguishable, and both Covid and the flu can be fatal to the elderly, the weak and the immunocompromised and that's why that group of people get a flu shot every Autumn, but what we don't do is force everyone else to get a flu shot too. I'd rather have the flu and allow my immune system to flex it's muscles than have a flu shot. So yes Covid is killing some people, but so is the flu. As callous as this sounds, that's life I'm afraid.

We need to move forward.

Those who got it wrong, for whatever reason, may feel defensive and retrench into a position that doesn’t accord with the facts.
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Post Options Post Options   Thanks (0) Thanks(0)   Quote Dutch Josh Quote  Post ReplyReply Direct Link To This Post Posted: July 21 2022 at 1:48am

KiwiMum, thanks for your reaction; 

Some points; 

-New Zealand did see at least 1,803 confirmed CoVid deaths so far...Global deaths at least [url]https://www.worldometers.info/coronavirus/[/url] or https://www.worldometers.info/coronavirus/ at 6,4 million...real number may be several times that number....

However I think different countries can choose different roads...Countries could learn from each other. 

-How many people did get infected. Worldometers has 572 million "positive tests"....also real number will be much higher...Is it 2 billion out of the almost 8 billion people on this planet ? Maybe even 4 billion ? Or "only" 1 billion "humans" ? As far as I know over 100 non-human species may have tested positive... This CoViD pandemic is multi-species...making it even harder to control...

-What role should governments play ? Good info could mean less government restrictions....I rather see good info-leaving people to make up their minds themselves....Freedom has responsability as the other side of that coin....

Like in the climate discussion however "freedom" should not mean destruction....Fossil fuel consumption has gone much to far much to long....A government can limit air travel to 5-10% of prepandemic...That at least would have some impact on both pandemics and climate change...

Political parties going for "freedom" without accepting "responsability" as the other side destabilize "nature" and we are facing the consequences of that now....

In a good functioning democracy governments have a limited-balanced-role....NOT a "nanny-state"....but governments -governing- means setting rules...From taxation (a.o. to have healthcare) to a (sort of) prison/correction system...I think that is what a governments job is....

To fight pandemics (and other major problems; climate change, crime etc.) governments need public support...


We cannot solve our problems with the same thinking we used when we created them.
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Post Options Post Options   Thanks (0) Thanks(0)   Quote Dutch Josh Quote  Post ReplyReply Direct Link To This Post Posted: September 16 2022 at 1:52am

Lots of questions on "new better-for profit (NOT public healthcare priority #1!!!) vaccines";

[url]https://papers.ssrn.com/sol3/papers.cfm?abstract_id=4206070[/url] or https://papers.ssrn.com/sol3/papers.cfm?abstract_id=4206070 

Abstract


Students at North American universities risk disenrollment due to third dose COVID-19 vaccine mandates. We present a risk-benefit assessment of boosters in this age group and provide five ethical arguments against mandates. 


We estimate that 22,000 - 30,000 previously uninfected adults aged 18-29 must be boosted with an mRNA vaccine to prevent one COVID-19 hospitalisation. 


Using CDC and sponsor-reported adverse event data, we find that booster mandates may cause a net expected harm: per COVID-19 hospitalisation prevented in previously uninfected young adults, we anticipate 18 to 98 serious adverse events, including 1.7 to 3.0 booster-associated myocarditis cases in males, and 1,373 to 3,234 cases of grade ≥3 reactogenicity which interferes with daily activities. 


Given the high prevalence of post-infection immunity, this risk-benefit profile is even less favourable. 


University booster mandates are unethical because: 

-1) no formal risk-benefit assessment exists for this age group; 

-2) vaccine mandates may result in a net expected harm to individual young people; 

-3) mandates are not proportionate: expected harms are not outweighed by public health benefits given the modest and transient effectiveness of vaccines against transmission; 

-4) US mandates violate the reciprocity principle because rare serious vaccine-related harms will not be reliably compensated due to gaps in current vaccine injury schemes; 

and 

-5) mandates create wider social harms. We consider counter-arguments such as a desire for socialisation and safety and show that such arguments lack scientific and/or ethical support. 


Finally, we discuss the relevance of our analysis for current 2-dose CCOVIDovid-19 vaccine mandates in North America.

DJ-This US/UK study is devastating.....are humans (or countries) used a testcases for vaccines ? Some claim Israel was used to test Pfizer vaccines...since it did not have a VAERS/adverse reaction administration... 

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Post Options Post Options   Thanks (0) Thanks(0)   Quote Dutch Josh Quote  Post ReplyReply Direct Link To This Post Posted: September 22 2022 at 3:57am

[url]https://www.youtube.com/watch?v=WjG3VoX3Ldk[/url] or https://www.youtube.com/watch?v=WjG3VoX3Ldk Dr. John Campbell on excess deaths...

Questions on safety of vaccines did result in youtube warning/censorship...Totally unacceptable !

We cannot solve our problems with the same thinking we used when we created them.
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Post Options Post Options   Thanks (0) Thanks(0)   Quote Dutch Josh Quote  Post ReplyReply Direct Link To This Post Posted: September 22 2022 at 10:31pm

Welcome good news;

[url]https://www.thailandmedical.news/news/breakthrough-mice-study-shows-that-prophylactic-intranasal-administration-of-sars-cov-2-specific-immunoglobulin-y-protects-against-covid-19[/url] or https://www.thailandmedical.news/news/breakthrough-mice-study-shows-that-prophylactic-intranasal-administration-of-sars-cov-2-specific-immunoglobulin-y-protects-against-covid-19  

link to; [url]https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1010782[/url] or https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1010782 ;

Abstract

Safe, passive immunization methods are required against severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) and its variants. Immunization of chickens with antigen is known to induce specific IgY antibodies concentrated in the egg yolk and has a good safety profile, high yield of IgY per egg, can be topically applied, not requiring parenteral delivery.

 Our data provide the first evidence of the prophylactic efficacy of Immunoglobulin Y antibodies against SARS-CoV-2 in mice. Lohmann hens were injected with recombinant SARS-CoV-2 RBD protein; IgY-Abs were extracted from the eggs and characterized using SDS-PAGE. Antiviral activity was evaluated using plaque reduction neutralization tests.

 In additional experiments, IgY-RBD efficacy was examined in mice sensitized to SARS-CoV-2 infection by transduction with Ad5-hACE2 (mild disease) or by using mouse-adapted virus (severe disease). 

In both cases, prophylactic intranasal administration of IgY-Abs reduced SARS-CoV-2 replication, and reduced morbidity, inflammatory cell infiltration, hemorrhage, and edema in the lungs and increased survival compared to control groups that received non-specific IgY-Abs. These results indicate that further evaluation of IgY-RBD antibodies in humans is warranted.

Author summary

We report the generation, characterization and antiviral activity of egg yolk derived IgY-Abs against the SARS-CoV-2 Receptor Binding Domain. Using two different models of murine SARS-CoV-2 infection, we show that intranasal prophylactic administration of IgY-Abs reduced viral replication, and reduced inflammatory cell infiltration, hemorrhage, and edema in the lungs.

DJ, studies on nasal vaccines have been going on for two years...It may be able to get us out of this pandemic...(I hope !)

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Post Options Post Options   Thanks (0) Thanks(0)   Quote Dutch Josh Quote  Post ReplyReply Direct Link To This Post Posted: September 26 2022 at 9:54am

More "nasal vaccine news";

[url]https://www.coronaheadsup.com/health/treatment/research-nasal-saline-irrigation-reduces-severity-in-high-risk-covid-patients/[/url] or https://www.coronaheadsup.com/health/treatment/research-nasal-saline-irrigation-reduces-severity-in-high-risk-covid-patients/ ;

SARS-CoV-2 positive participants initiating nasal irrigation were over 8 times less likely to be hospitalized than the national rate.

Seventy-nine high-risk participants were enrolled. Analyzed by intention-to-treat, by day 28, COVID-19 symptoms resulted in one ED visit and no hospitalizations in 42 irrigating with alkalinization, one hospitalization of 37 in the povidone-iodine group, (1.27%) and no deaths.

Eleven reported irrigation-related complaints and four discontinued use. Symptom resolution was more likely for those reporting twice daily irrigation

Rapid initiation of nasal saline irrigation to reduce severity in high-risk COVID+ outpatients

 

Starting twice daily flushing of the mucus-lined nasal cavity with a mild saline solution soon after testing positive for COVID-19 can significantly reduce hospitalization and death, investigators report.

They say the technique that can be used at home by mixing a half teaspoon each of salt and baking soda in a cup of boiled or distilled water then putting it into a sinus rinse bottle is a safe, effective and inexpensive way to reduce the risk of severe illness and death from coronavirus infection that could have a vital public health impact.

Eurekalert.org article

 


Amazon nasal Irrigation sinus rinse kit for adults and kids

DJ, Nasal vaccines may-by technique- do better then traditional vaccinations in a muscle.

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Post Options Post Options   Thanks (0) Thanks(0)   Quote Dutch Josh Quote  Post ReplyReply Direct Link To This Post Posted: November 10 2022 at 2:27am

Some latest info on vaccines [url]https://www.independentsage.org/demystifying-and-debunking-mrna-vaccines/[/url] or https://www.independentsage.org/demystifying-and-debunking-mrna-vaccines/ 

DJ-Vaccines are just part of the story...If you want to see "CoViD as a flu" -and you also never go for flu-vaccines-I think you may be "double wrong"...but you have a right to choose...

In my opinion CoViD-risks are increasing;

-newer variants able to evade better immunity (from both earlier infection and/or vaccines)

-CoViD may have long term health effects

-new variants could cause infection in other/more parts of the body

There was an "idea" CoViD would "become milder" over time-more cold like (maybe also based on idea's on the Russian 1890-flu-possibly being CoViD) however given the ongoing spread, extreme high numbers CoViD managed to get worse...

So-even as vaccines never will be 100% perfect-balancing risks and gains may (again) move towards getting vaccinated...

DJ-Even China has NO mandatory vaccinations (however testing may be mandatory)...so vaccines should ALWAYS be a choice-based on the best available info !

We cannot solve our problems with the same thinking we used when we created them.
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Post Options Post Options   Thanks (0) Thanks(0)   Quote badger2 Quote  Post ReplyReply Direct Link To This Post Posted: November 10 2022 at 9:33am

The Chinese military's SARS-like bat coronavirus, ZC45 spike protein, contains an RGD motif. SARS-CoV-2 spike protein RGD motif is at positions  403-405. HCov-229E coronavirus contains an RGD motif at positions 341-343.


The RGD motif links to integrin binding. Here we link integrin binding to the glomerular basement membrane:


Glomerular Basement Membrane-Derived Perlecan Inhibits Mesangial Cell Adhesion to Fibronectin

https://pubmed.ncbi.nlm.nih.gov/8832207

'....The resulting avidity level is too low for mediating cell binding but sufficient to induce integrin organization into focal contacts.'


4 Nov 2022  A Population-Based Analysis of Risk of Glomerular Kidney Disease Relapse After COVID-19 Vaccination

https://pubmed.ncbi.nlm.nih.gov/36332971

'....Glomerular kidney disease can worsen to complete kidney failure and dialysis, so the consequences are significant if there is a problem with mRNA, spike protein, and progression of disease.'


To have left out the RGD motif in Pfizer mRNA vaccine would have been a mistake for Pfizer, and this motif in the mRNA "vaccine" is likely implicated in glomerular kidney disease exacerbation.

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Post Options Post Options   Thanks (0) Thanks(0)   Quote Newbie1A Quote  Post ReplyReply Direct Link To This Post Posted: November 22 2022 at 8:18pm
If it's to be - it's up to me!
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Post Options Post Options   Thanks (0) Thanks(0)   Quote Usk Quote  Post ReplyReply Direct Link To This Post Posted: November 23 2022 at 7:52am

Please don’t post trash

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