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Online Discussion: Tracking new emerging diseases and the next pandemic since 2005; Coronavirus COVID-19 Pandemic Discussion Forum.

Predicting Long Covid
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Little House View Drop Down
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    Posted: January 23 2021 at 4:31am

https://www.medrxiv.org/content/10.1101/2020.10.19.20214494v2

I found this study that tried to figure out which patients would have long Covid.  They found that age and sex were related to long Covid, but also number of symptoms during the first week of illness. 

Patients who have more than 5 symptoms the first week seem to have a greater risk of long Covid.  Also, older women seem to be at greater risk.  

It is an interesting read.
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ViQueen24 View Drop Down
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Points: 9495 		Post Options Post Options   Thanks (0) Thanks(0)   Quote ViQueen24 Quote  Post ReplyReply Direct Link To This Post Posted: January 23 2021 at 9:53am

Inflammation is key.  Old people have more inflammation than young people, in general, and although premenopausal women have less inflammation than men of equivalent age, once they enter menopause, they no longer produce estrogen and progesterone, which protect them from inflammation, so they are very prone to inflammatory conditions such as arthritis, heart disease and diabetes, and within 8 years of menopause, usually catch up to the rates for those conditions of men of an equivalent age.
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KiwiMum View Drop Down
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Points: 19365 		Post Options Post Options   Thanks (0) Thanks(0)   Quote KiwiMum Quote  Post ReplyReply Direct Link To This Post Posted: January 23 2021 at 11:15am

Originally posted by ViQueen24 ViQueen24 wrote:

Inflammation is key.  Old people have more inflammation than young people, in general, and although premenopausal women have less inflammation than men of equivalent age, once they enter menopause, they no longer produce estrogen and progesterone, which protect them from inflammation, so they are very prone to inflammatory conditions such as arthritis, heart disease and diabetes, and within 8 years of menopause, usually catch up to the rates for those conditions of men of an equivalent age.

I did read something a few weeks ago that suggested menopausal women taking HRT were faring better then their peers who weren't taking HRT, so presumably the hormone factor is key in that age bracket of women.
You can't fix stupid.
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ViQueen24 View Drop Down
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Points: 9495 		Post Options Post Options   Thanks (0) Thanks(0)   Quote ViQueen24 Quote  Post ReplyReply Direct Link To This Post Posted: January 24 2021 at 2:20pm

This is why I think a post from Chuck might be one of the most crucial to those who get the virus.  

https://www.avianflutalk.com/antiinflammatory-meds_topic42525.html

Scroll all the way to the bottom for Chuck's post, where he talks about various biologics like Otezla and Embrel that looked promising.  I wonder how that study turned out?
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