According to CDC definitions; [url]https://www.cdc.gov/coronavirus/2019-ncov/variants/variant-info.html#:~:text=A%20variant%20of%20high%20consequence,relative%20to%20previously%20circulating%20variants.[/url] or https://www.cdc.gov/coronavirus/2019-ncov/variants/variant-info.html#:~:text=A%20variant%20of%20high%20consequence,relative%20to%20previously%20circulating%20variants. - https://www.cdc.gov/coronavirus/2019-ncov/variants/variant-info.html#:~:text=A%20variant%20of%20high%20consequence,relative%20to%20previously%20circulating%20variants. ;

Variant of High Consequence (VOHC)

A variant of high consequence has clear evidence that prevention measures or medical countermeasures (MCMs) have significantly reduced effectiveness relative to previously circulating variants. 

Possible attributes of a variant of high consequence: 

In addition to the possible attributes of a variant of concern

• Impact on Medical Countermeasures (MCM)
  • Demonstrated failure of diagnostic test targets
  • Evidence to suggest a significant reduction in vaccine effectiveness, a disproportionately high number of infections in vaccinated persons, or very low vaccine-induced protection against severe disease
  • Significantly reduced susceptibility to multiple Emergency Use Authorization (EUA) or approved therapeutics
  • More severe clinical disease and increased hospitalizations

A variant of high consequence would require notification to WHO under the International Health Regulations, reporting to CDC, an announcement of strategies to prevent or contain transmission, and recommendations to update treatments and vaccines. 

DJ Why is Delta (+) not yet a VOHC ????? Because it is not "just" one virus but on ongoing proces-most likely resulting in evading immunity variants ???

[url]https://outbreak.info/situation-reports[/url] or  https://outbreak.info/situation-reports - https://outbreak.info/situation-reports  has allready 151 sub-variants of Delta !