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SARS-3 ????

Printed From: COVID-19 / South Africa Omicron Variant
Category: Main Forums
Forum Name: Latest News
Forum Description: (Latest Breaking News)
URL: http://www.avianflutalk.com/forum_posts.asp?TID=44994
Printed Date: March 28 2024 at 11:17am


Topic: SARS-3 ????
Posted By: Dutch Josh
Subject: SARS-3 ????
Date Posted: September 24 2022 at 5:29am

[url]https://www.coronaheadsup.com/health/animals/bats/preprint-russian-khosta-2-bat-virus-resistant-to-sars-cov-2-vaccines/[/url] or https://www.coronaheadsup.com/health/animals/bats/preprint-russian-khosta-2-bat-virus-resistant-to-sars-cov-2-vaccines/ - https://www.coronaheadsup.com/health/animals/bats/preprint-russian-khosta-2-bat-virus-resistant-to-sars-cov-2-vaccines/ ;

“We found that the spike from virus, Khosta-2, could infect cells similar to human pathogens using the same entry mechanisms, but was resistant to neutralization by serum from individuals who had been vaccinated for SARS-CoV-2.”.

Khosta-2, a sarbecovirus discovered in Russia, has been shown to interact with the same entry receptor as SARS-CoV-2. In this study, we tested how well the spike proteins from these bat viruses infect human cells under different conditions. We found that the spike from virus, Khosta-2, could infect cells similar to human pathogens using the same entry mechanisms, but was resistant to neutralization by serum from individuals who had been vaccinated for SARS-CoV-2.

To assess if the ACE2-dependent Khosta 2 RBD and SARS-CoV-2 RBD were cross-reactive, we incubated pseudotyped particles with increasing amounts of the SARS-CoV-2 RBD-specific monoclonal antibody, Bamlanivimab. Surprisingly, while SARS-CoV-2 spike was effectively neutralized by the antibody, the SARS-CoV-2 spike with the Khosta 2 RBD was completely resistant, suggesting little cross-reactivity between the two RBDs

Preprint: An ACE2-dependent Sarbecovirus in Russian bats is resistant to SARS-CoV-2 vaccines

see also; [url]https://www.coronaheadsup.com/asia/china/bats-in-thailand-found-with-coronaviruses-similar-to-sars-cov-2/[/url] or https://www.coronaheadsup.com/asia/china/bats-in-thailand-found-with-coronaviruses-similar-to-sars-cov-2/ - https://www.coronaheadsup.com/asia/china/bats-in-thailand-found-with-coronaviruses-similar-to-sars-cov-2/ from february 2021...

Corona virusses are widespread...SARS-1, MERS may be only the tip of an iceberg. Russian Flu [url]https://en.wikipedia.org/wiki/1889%E2%80%931890_pandemic[/url] or https://en.wikipedia.org/wiki/1889%E2%80%931890_pandemic - https://en.wikipedia.org/wiki/1889%E2%80%931890_pandemic ;Although contemporaries described the pandemic as  https://en.wikipedia.org/wiki/Influenza" style="text-decoration: none; color: rgb(6, 69, 173); background: none rgb(255, 255, 255); font-family: sans-serif; font-size: 14px; font-style: normal; font-variant-ligatures: normal; font-variant-caps: normal; font-weight: 400; letter-spacing: normal; orphans: 2; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px; -webkit-text-stroke-width: 0px;" title="Influenza - influenza  and twentieth-century scholars identified several influenza strains as the possible pathogen, some more recent authors suggest that it may have been caused by  https://en.wikipedia.org/wiki/Human_coronavirus_OC43" style="text-decoration: none; color: rgb(6, 69, 173); background: none rgb(255, 255, 255); font-family: sans-serif; font-size: 14px; font-style: normal; font-variant-ligatures: normal; font-variant-caps: normal; font-weight: 400; letter-spacing: normal; orphans: 2; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px; -webkit-text-stroke-width: 0px;" title="Human coronavirus OC43 - human coronavirus OC43 . https://en.wikipedia.org/wiki/1889%E2%80%931890_pandemic#cite_note-OC43-6" style="text-decoration: none; color: rgb(6, 69, 173); background: none; - [6] https://en.wikipedia.org/wiki/1889%E2%80%931890_pandemic#cite_note-corona-7" style="text-decoration: none; color: rgb(6, 69, 173); background: none; - [7] https://en.wikipedia.org/wiki/1889%E2%80%931890_pandemic#cite_note-Van_Ranst-8" style="text-decoration: none; color: rgb(6, 69, 173); background: none; - [8] https://en.wikipedia.org/wiki/1889%E2%80%931890_pandemic#cite_note-King-9" style="text-decoration: none; color: rgb(6, 69, 173); background: none; - [9]

and [url]https://en.wikipedia.org/wiki/Chronic_fatigue_syndrome#Viral_and_other_infections[/url] or https://en.wikipedia.org/wiki/Chronic_fatigue_syndrome#Viral_and_other_infections - https://en.wikipedia.org/wiki/Chronic_fatigue_syndrome#Viral_and_other_infections may have corona-virus links. 

CoViD-19/SARS-2 most likely will NOT be the last [url]https://en.wikipedia.org/wiki/Coronavirus[/url] or  https://en.wikipedia.org/wiki/Coronavirus - https://en.wikipedia.org/wiki/Coronavirus  bringing large scale disease...Certainly CoViD resulting in a decrease of immunity may open doors for other corona virus spread...



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We cannot solve our problems with the same thinking we used when we created them.
~Albert Einstein



Replies:
Posted By: Dutch Josh
Date Posted: November 13 2022 at 9:39am

[url]https://www.thailandmedical.news/news/u-s-study-shows-that-sars-cov-2-has-already-spread-extensively-in-the-wildlife-expect-debut-of-sars-cov-3-sometime-in-2023[/url] or https://www.thailandmedical.news/news/u-s-study-shows-that-sars-cov-2-has-already-spread-extensively-in-the-wildlife-expect-debut-of-sars-cov-3-sometime-in-2023 - https://www.thailandmedical.news/news/u-s-study-shows-that-sars-cov-2-has-already-spread-extensively-in-the-wildlife-expect-debut-of-sars-cov-3-sometime-in-2023 link to [url]https://www.biorxiv.org/content/10.1101/2022.11.04.515237v1[/url] or https://www.biorxiv.org/content/10.1101/2022.11.04.515237v1 - https://www.biorxiv.org/content/10.1101/2022.11.04.515237v1 ;

Abstract

The spillover of SARS-CoV-2 into humans has caused one of the most devastating pandemics in recorded history. Human-animal interactions have led to transmission events of SARS-CoV-2 from humans to wild and captive animals. However, many questions remain about how extensive SARS-CoV-2 exposure is in wildlife, the factors that influence wildlife transmission risk, and whether sylvatic cycles can generate novel variants with increased infectivity and virulence. We sampled 18 different wildlife species in the Eastern U.S. and detected widespread exposure to SARS-CoV-2 across wildlife species. Using quantitative reverse transcription polymerase chain reaction and whole genome sequencing, we conclusively detected SARS-CoV-2 in the Virginia opossum and had equivocal detections in six additional species. Species considered human commensals like squirrels, and raccoons had high seroprevalence, ranging between 62%-71%, and sites with high human use had three times higher seroprevalence than low human-use areas. SARS-CoV-2 genomic data from an infected opossum and molecular modeling exposed previously uncharacterized changes to amino acid residues observed in the receptor binding domain (RBD), which predicts improved binding between the spike protein and human angiotensin-converting enzyme (ACE2) compared to the dominant variant circulating at the time of isolation. These mutations were not identified in human samples at the time of collection. Overall, our results highlight widespread exposure to SARS-CoV-2 in wildlife and suggest that areas with high human activity may serve as important points of contact for cross-species transmission. Furthermore, this work highlights the potential role of wildlife in fueling de novo mutations that may eventually appear in humans.

DJ...of course bats themselves have (round) 30 corona virus types....so mutations there could bring new types of CoViD/SARS...CoViD-spread via birds (in combination with flu types) could be another bad change...

TMN claims the real number of cases/deaths are 5 to 6 time the official numbers...640 million cases, 6,6 million deaths would then translate to 3,2/3,8 billion cases-almost 50% of the global population....(if you would exclude reinfections...33 to 39 million deaths....

One could argue the spread in humans may bring SARS-3...depending on definition mutations may result in variants very different from the "Wuhan-wild type"....

There was the idea SARS-1 infection would result in immunity against "SARS-2"...I think that idea is history by now.... 



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We cannot solve our problems with the same thinking we used when we created them.
~Albert Einstein


Posted By: Dutch Josh
Date Posted: January 04 2023 at 9:34am

[url]https://twitter.com/YouAreLobbyLud/status/1610617921692131334[/url] or https://twitter.com/YouAreLobbyLud/status/1610617921692131334 - https://twitter.com/YouAreLobbyLud/status/1610617921692131334 XBB.1.5

link to [url]https://www.biorxiv.org/content/10.1101/2022.11.23.517532v1.full.pdf[/url] or https://www.biorxiv.org/content/10.1101/2022.11.23.517532v1.full.pdf - https://www.biorxiv.org/content/10.1101/2022.11.23.517532v1.full.pdf  


Conversation












Posted By: Dutch Josh
Date Posted: January 04 2023 at 9:35am

[url]https://www.coronaheadsup.com/science/variants/recombinants/xbb-1-5/xbb-1-5-has-a-much-higher-hace2-binding-affinity-than-xbb-1/[/url] or https://www.coronaheadsup.com/science/variants/recombinants/xbb-1-5/xbb-1-5-has-a-much-higher-hace2-binding-affinity-than-xbb-1/ - https://www.coronaheadsup.com/science/variants/recombinants/xbb-1-5/xbb-1-5-has-a-much-higher-hace2-binding-affinity-than-xbb-1/   DJ-If I edit the above twitter story I may end up destroying it...



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We cannot solve our problems with the same thinking we used when we created them.
~Albert Einstein



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