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What you don’t know about whooping cough

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    Posted: February 05 2007 at 3:01pm
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What you don't know about whooping cough
 
 
Bordetella Pertussis
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"...A prolonged cough alone is presumptively considered to be a case of pertussis during a known outbreak...."
 

Pertussis Infection in Adults
.......................................
 
 
SETH W. WRIGHT, MD, MPH, Nashville, Tenn
 
 
 
excerpts...
 
 
 
"...Nevertheless, it is now evident that, because of waning immunity
from childhood vaccination,
pertussis infection is common in adults.
Physicians need to be familiar with pertussis in adults. Adults are the major reservoir of disease; susceptible infants may acquire pertussis
not only from another child, but also from an infected adult...."
 
 
 
"...The disease is also costly since patients may be evaluated many times, may have expensive diagnostic tests done, and often are prescribed
multiple courses of antibiotics..."
 

 
"...fact, more annual deaths were reported from
pertussis than from meningitis, scarlet fever,
measles, diphtheria, and poliomyelitis combined...."
 
 
 
"...The fact that pertussis is not solely a disease of children has been recognized for many years..."
 
......................................................................................................
 
 
According to the CDC.... There is no reliable measure of immunity to pertussis
 
 
The Vaccines don't seem to ...last.

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Pertussis
 
There is no reliable measure of immunity to pertussis since it is difficult to determine the correlation between the levels of antibodies against specific pertussis antigens and level of protective immunity developed by animals or human subjects given the vaccine.
 
 
Furthermore,
the persistence of immunity to pertussis
 
following the three primary doses of the combination vaccine diphtheria, tetanus, pertussis (DTP)
 
is not well established.

 
A Finnish study following an outbreak
suggests that protection against pertussis conferred by the 3 doses given in infancy
 
 
lasts for about one year,
 
 
and protection following a fourth dose (booster) persists another
 
 
2 to 3 years (see reference 28).

.............................................................................................................
 
 

 
 
This work also points out "the importance of supporting a cadre of basic researchers," added Flicker, "who can quickly apply their expertise to national medical emergencies."
 
Tang's studies suggest that adefovir may also inhibit similar toxins produced by more common disease-causing bacteria including:
 
Bordetella pertussis, which causes whooping cough;
 
Yersinia pestis, which causes plague, and
 
Pseudomonas aeruginosa, a common cause of hospital-acquired infections and a scourge for patients with cystic fibrosis.
 
 
All three are also considered potential bioterror agents.
 
...........................................................................................................

 
Most bacterial pathogens do not invade cells, proliferating instead in the extracellular environment enriched by body fluids.
 
Some of these bacteria (e.g., V cholerae and Bordetella pertussis) do not even penetrate body tissues, but, rather, adhere to epithelial surfaces and cause disease by secreting potent protein toxins
..........................................................................................................................................
 

 
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FOOD AND DRUG ADMINISTRATION

 

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   CENTER FOR BIOLOGICS EVALUATION AND RESEARCH

 

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     VACCINES AND RELATED BIOLOGICAL PRODUCTS

                ADVISORY COMMITTEE

 

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             MEETING BY TELECONFERENCE

 

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                   OPEN SESSION

This transcript has not been edited or corrected, but appears as received from the commercial transcribing service.  Accordingly the Food and Drug Administration makes no representation as to its accuracy.

 

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                     THURSDAY

                SEPTEMBER 22, 2005

 

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excerpt...
 
 
First, I have a research program, a small program in both Bordetella pertussis and Bacillus anthracis.  While each program is small, I think that it is important to have a program in each of these areas to give the people who are doing the regulation hands-on expertise in those areas, and it also gives us credibility in each of those individual fields.

            My program on Bordetella pertussis in both structure/function studies of pertussis toxin and specifically, we focus lately on the studies on the mechanism of action of secretion of pertussis toxin.  My program on Bacillus anthracis focuses on the role of surface proteins in virulence.

            Tod Merkel's research:  Again, he has two areas of research, one on Bacillus anthracis, one on Bordetella pertussis, because he and his group are responsible for both of those areas as far as regulation is concerned.

            He has identified important virulence factors in Bacillus anthracis and done a very nice job of developing a mouse aerosol challenge model for inhalation anthrax that has really been an important resource both for our Center as well as a number of members of the academic community.  His work on Bordetella pertussis involves characterization of critical virulence regulatory pathways.

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Search Results

Your search for Bordetella returned 2 results. Here are results 1 - 2.

1. FSAI - Human Data ••
...Bordetella pertussis Plague Yersinia pestis Q Fever Coxiella burnetii Rabies Rabies virus Rubella Rubella virus...
Date: No Date Address: http://www.fsai.ie/surveillance/human/surveillance_human_notification.asp

2. FSAI - Zoonoses - Notifiable Diseases in Humans ••
...• Pertussis [Bordetella pertussi] • Plague [Yersinia pestis] • Q Fever [Coxiella burnetii] • Rabies [Rabies virus] • Rubella [Rubella virus]...
Date: No Date Address: http://www.fsai.ie/surveillance/human/surveillance_human_zoonoses_humans.asp

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.
 
 
Patent No. Patent Title: Issue Date:
7105161 Proteinaceous adjuvants
A modulated immune response to an antigen is achieved by coadministering the antigen and a genetically-detoxified pertussis holotoxin, particularly one retaining its immunogenicity, to a host. The modulated immune response enables immunogenic compositions, including multivalent pediatric...
2006-09-12
7105317 Immunogenic compositions comprising vrg-gene products from Bordetella extracts
This invention relates to an immunogenic composition comprising a bacterial extract containing at least one expression products of the vrg genes of a strain of Bordetella chosen from B. pertussis, B. parapertussis, or B. bronchiseptica. The invention also relates to a method for producing the...
2006-09-12
7087236 Method for inducing a cell-mediated immune response and improved parenteral...
A method of inducing either a TH1 polarized immune response, a TH2 polarized immune response or a combined TH1 and TH2 response to an antigen and associated vaccine formulations are disclosed. A method is provided for inducing a polarized TH1 response by parenteral administration of...
2006-08-08
7070781 Nontoxic mucosal adjuvant
A non-toxic mucosal adjuvant is provided which may be admixed with further antigens to provide a vaccine administrable to mucosal surfaces in organisms including man. Preferably, the non-toxic mucosal adjuvant is a detoxified mutant of a bacterial ADP-ribosylating toxin, optionally comprising...
2006-07-04
7070779 POLYPEPTIDES CONTAINING POLYMORPHISMS OF THE REPEATED REGIONS OF PERTACTIN IN...
Pertactin (PRN) is an outer membrane protein expressed by Bordetella pertussis, Bordetella parapertussis, and Bordetella bronchiseptica, which induces protective immunity to Bordetella infections. The immunodominant and immunoprotective epitopes of pertactin include two repeated regions, I and...
2006-07-04
7056521 Detoxified mutants of bacterial ADP-ribosylating toxins as parenteral adjuvants
The present invention provides parenteral adjuvants comprising detoxified mutants of bacterial ADP-ribosylating toxins, particularly those from pertussis (PT), cholera (CT), and heat-labile E. coli (LT).
2006-06-06
6929794 IL-12 as an adjuvant for Bordetella pertussis vaccines
This invention provides a composition of at least one Bordetella antigen and an effective adjuvant amount of interleukin-12 (IL-12), and uses thereof as a vaccine against Bordetella infection. Methods for using IL-12 as an adjuvant in combination with vaccines against Bordetella are...
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Post Options Post Options   Thanks (0) Thanks(0)   Quote MitchM Quote  Post ReplyReply Direct Link To This Post Posted: February 05 2007 at 9:00pm
Thanks for the post, that was indeed an interesting read!
Are you Bird Flu prepared? The Secrets All Revealed!
http://www.YouMustPrepare.com
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I am learning so many things on these boards, that have nothing to do with BF, but sure could save a life.

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