Now tracking the new emerging South Africa Omicron Variant |
What you dont know about whooping cough |
Post Reply |
Author | |||||||||||||||||||||||
Guests
Guest Group |
Post Options
Thanks(0)
Posted: February 05 2007 at 3:01pm |
||||||||||||||||||||||
...
What you don't know about whooping cough Bordetella Pertussis
..................................... "...A prolonged cough alone is presumptively considered to be a case of pertussis during a known outbreak...."
Pertussis Infection in Adults .......................................
SETH W. WRIGHT, MD, MPH, Nashville, Tenn
excerpts...
"...Nevertheless, it is now evident that, because of waning immunity
from childhood vaccination, pertussis infection is common in adults. Physicians need to be familiar with pertussis in adults. Adults are the major reservoir of disease; susceptible infants may acquire pertussis not only from another child, but also from an infected adult...." "...The disease is also costly since patients may be evaluated many times, may have expensive diagnostic tests done, and often are prescribed
multiple courses of antibiotics..." "...fact, more annual deaths were reported from
pertussis than from meningitis, scarlet fever, measles, diphtheria, and poliomyelitis combined...." "...The fact that pertussis is not solely a disease of children has been recognized for many years..."
......................................................................................................
According to the CDC.... There is no reliable measure of immunity to pertussis
The Vaccines don't seem to ...last.
........................................................................................................ Pertussis There is no reliable measure of immunity to pertussis since it is difficult to determine the correlation between the levels of antibodies against specific pertussis antigens and level of protective immunity developed by animals or human subjects given the vaccine.
Furthermore,
the persistence of immunity to pertussis
following the three primary doses of the combination vaccine diphtheria, tetanus, pertussis (DTP)
is not well established.
A Finnish study following an outbreak
suggests that protection against pertussis conferred by the 3 doses given in infancy
lasts for about one year,
and protection following a fourth dose (booster) persists another
2 to 3 years (see reference 28).
............................................................................................................. This work also points out "the importance of supporting a cadre of basic researchers," added Flicker, "who can quickly apply their expertise to national medical emergencies."
Tang's studies suggest that adefovir may also inhibit similar toxins produced by more common disease-causing bacteria including:
Bordetella pertussis, which causes whooping cough;
Yersinia pestis, which causes plague, and
Pseudomonas aeruginosa, a common cause of hospital-acquired infections and a scourge for patients with cystic fibrosis.
All three are also considered potential bioterror agents.
...........................................................................................................
Most bacterial pathogens do not invade cells, proliferating instead in the extracellular environment enriched by body fluids.
Some of these bacteria (e.g., V cholerae and Bordetella pertussis) do not even penetrate body tissues, but, rather, adhere to epithelial surfaces and cause disease by secreting potent protein toxins
..........................................................................................................................................
|
|||||||||||||||||||||||
Guests
Guest Group |
Post Options
Thanks(0)
|
||||||||||||||||||||||
Guests
Guest Group |
Post Options
Thanks(0)
|
||||||||||||||||||||||
FOOD AND DRUG ADMINISTRATION
+ + + + + CENTER FOR BIOLOGICS EVALUATION AND RESEARCH + + + + + VACCINES AND RELATED BIOLOGICAL PRODUCTS ADVISORY COMMITTEE + + + + + MEETING BY TELECONFERENCE + + + + + OPEN SESSION This transcript has not been edited or corrected, but appears as received from the commercial transcribing service. Accordingly the Food and Drug Administration makes no representation as to its accuracy. + + + + + THURSDAY SEPTEMBER 22, 2005 + + + + + excerpt...
First, I have a research program, a small program in both Bordetella pertussis and Bacillus anthracis. While each program is small, I think that it is important to have a program in each of these areas to give the people who are doing the regulation hands-on expertise in those areas, and it also gives us credibility in each of those individual fields.
My program on Bordetella pertussis in both structure/function studies of pertussis toxin and specifically, we focus lately on the studies on the mechanism of action of secretion of pertussis toxin. My program on Bacillus anthracis focuses on the role of surface proteins in virulence. Tod Merkel's research: Again, he has two areas of research, one on Bacillus anthracis, one on Bordetella pertussis, because he and his group are responsible for both of those areas as far as regulation is concerned. He has identified important virulence factors in Bacillus anthracis and done a very nice job of developing a mouse aerosol challenge model for inhalation anthrax that has really been an important resource both for our Center as well as a number of members of the academic community. His work on Bordetella pertussis involves characterization of critical virulence regulatory pathways. |
|||||||||||||||||||||||
Guests
Guest Group |
Post Options
Thanks(0)
|
||||||||||||||||||||||
Search ResultsYour search for Bordetella returned 2 results. Here are results 1 - 2. 1. FSAI - Human Data •• 2. FSAI - Zoonoses - Notifiable Diseases in Humans •• |
|||||||||||||||||||||||
Guests
Guest Group |
Post Options
Thanks(0)
|
||||||||||||||||||||||
.
|
|||||||||||||||||||||||
MitchM
Experienced Member Joined: February 05 2007 Status: Offline Points: 13 |
Post Options
Thanks(0)
|
||||||||||||||||||||||
Thanks for the post, that was indeed an interesting read!
|
|||||||||||||||||||||||
Are you Bird Flu prepared? The Secrets All Revealed!
http://www.YouMustPrepare.com |
|||||||||||||||||||||||
Guests
Guest Group |
Post Options
Thanks(0)
|
||||||||||||||||||||||
I am learning so many things on these boards, that have nothing to do with BF, but sure could save a life. |
|||||||||||||||||||||||
Post Reply | |
Tweet
|
Forum Jump | Forum Permissions You cannot post new topics in this forum You cannot reply to topics in this forum You cannot delete your posts in this forum You cannot edit your posts in this forum You cannot create polls in this forum You can vote in polls in this forum |